Results 101 to 110 of about 5,994,958 (304)

Child Abuse Reporting: Rethinking Child Protection [PDF]

open access: yes, 2012
The general public has been bewildered by the magnitude of sex abuse cases and the widespread failure by pillars of the community to notify appropriate authorities.
Cole, Thomas B.   +2 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Evidence-based practice and practice-based evidence [PDF]

open access: yes
This policy brief outlines the complexities involved in selecting interventions for early childhood services. It advocates for a broader method of assessing outcomes of interventions through incorporating practice-based evidence into our ...
Centre for Community Child Health
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Transforming Front-Line Child Welfare Practice: The Impacts of Institutional Settings on Services, Employment Environments, Children, and Families (SYNTHESIS REPORT) [PDF]

open access: yes, 2010
In 2006, the Ontario government launched an ambitious and multi-faceted Transformation Agenda for child welfare services. Among this Agenda’s objectives was the development of more cooperative helping relationships in child welfare, reducing the system’s
Cameron, Gary   +2 more
core   +4 more sources

Access to Tacit Knowledge by Executive Retention in Cross-border Acquisitions [PDF]

open access: yesBAR: Brazilian Administration Review, 2012
For companies that are internationalizing through foreign acquisitions, a major consideration is likely to be access to the technical and social knowledge of the local environment that executives of the acquired companies possess. Despite the importance
John Child   +3 more
doaj  

Towards an Early Years Learning Framework [PDF]

open access: yes
The Australian and state and territory governments are committed to the development of a national Early Years Learning Framework, and a process of consultation with the early childhood sector about the nature and content of the Framework is currently ...
Centre for Community Child Health
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Integrating services for young children and their families [PDF]

open access: yes
In an effort to improve outcomes for young children and their families, governments in all developed nations are making efforts to integrate services more effectively.
Centre for Community Child Health
core  

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