Results 111 to 120 of about 5,994,958 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Frontiers in EndocrinologyIntroductionThis review examines the evolution of gonadotrophins in ovarian stimulation (OS) protocols for assisted reproductive techniques (ART). Since the advent of in vitro fertilisation (IVF) in the late 1970s, the pharmaceutical industry has played ...
Tim Child +3 more
doaj +1 more source
Rethinking the transition to school: linking schools and early years services [PDF]
Starting school is an exciting but also potentially stressful time for children and families alike. It is one of the key transition points during childhood.
Centre for Community Child Health
core
Child Labour in Latin America [PDF]
, 2005 Fact sheet on child labor in Latin America, compiled by the International Labour Organization (ILO) in ...
International Labour Organization
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Using Repeat Photography to Observe Vegetation Change Over Time in Gorongosa National Park
African Studies Quarterly, 2017 Protected areas are important conservation tools, as they can be managed to preserve baseline ecosystem health, including that of vegetation dynamics. Understanding long-term ecosystem dynamics within a protected area enables one to understand how this ...
Hannah V. Herrero +3 more
doaj
Use of cannabis in pregnancy and as a new parent [PDF]
The most common illicit drug used by women of reproductive age and by pregnant women is cannabis (DrugInfo, 2005). Although there are limited national data available on illicit substance use among parents in Australia, the 2007 National Drug Strategy ...
Centre for Community Child Health
core
Child care subsidies critical for low-income families amid rising child care expenses [PDF]
, 2013 The high cost of child care is a barrier to employment among low-income families with young children. Child care subsidies are designed to support both parental employment and child development by lowering the cost of child care and making high-quality ...
Adams, Nicholas, Smith, Kristin
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source