Results 91 to 100 of about 5,994,958 (304)
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
There is much received wisdom on infant sleep and new parents will find that just about everyone they speak to has an opinion – where, how much, how often.
Centre for Community Child Health
core
Rising to the Challenge: The Strategies of Social Service Intermediaries [PDF]
, 2012 During the past decade, "intermediary organizations" have proliferated across the nonprofit sector. These organizations are typically positioned between funding entities (e.g., government agencies, foundations and corporations) and direct service ...
Child Trends +2 more
core
Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Child Labour in the Russian Federation [PDF]
, 2002 Working paper on child labor written in 2002 for the ILO by Svetlana Stephenson, in preparation of the ILO Declaration entitled A Future Without Child Labour, under the mandate of the ILO Declaration on Fundamental Principles and Rights at ...
International Labour Office +1 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Genotoxic assessment of a Cannabis sativa L. extract
Pharmaceutical BiologyContext As a naturally occurring terpenoid found in Cannabis sativa L. (Cannabaceae), cannabidiol (CBD) has gained public and industry interest for the purposes of personal well-being as a foodstuff and pharmaceutical. Despite a number of publications on
Mark J. Tallon +2 more
doaj +1 more source
The changing role of grandparents [PDF]
Recent changes in family and society have meant that the roles grandparents take on have changed. Many grandparents are playing a bigger and more responsible part of grandchild care than they may have expected, which means additional pressures on their ...
Centre for Community Child Health
core