Results 81 to 90 of about 19,059,317 (408)

Is the Families First Home Visiting Program Effective in Reducing Child Maltreatment and Improving Child Development?

Child Maltreatment, 2017
While home visiting programs are among the most widespread interventions to support at-risk families, there is a paucity of research investigating these programs under real-world conditions.
Mariette J. Chartier, M. Brownell, Michael R Isaac, D. Chateau, Nathan C. Nickel, A. Katz, Joykrishna Sarkar, Milton Hu, Carole R Taylor   +8 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An examination of the hopelessness levels and self-esteem of parents with special needs children

BMC Psychology
Every parent dreams of having a child with typical development. However, parents may have a child with special needs due to any reason that occurs before or after birth. Having a child with special needs is a difficult situation to accept.
Nazan Kaytez, Bayram Deleş, Neriman Aral   +2 more
doaj   +1 more source

The Implementation of Families First in the Netherlands: A One Year Follow-up [IF: 0.725] [PDF]

, 2003
Contains fulltext : 63625.pdf (publisher's version ) (Closed access)This study examined whether the American family preservation program Families First was successfully implemented in the Netherlands. Data were collected on 250 children
Brink, L.T. ten, Kemp, R.A.T. de, Scholte, E.M., Slot, N.W., Veerman, J.W.   +4 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Transplantation of Amniotic Epithelial Cells into Fetal Rat Liver by In Utero Manipulation

Cell Transplantation, 2002
It has been hoped that amniotic epithelial cells would be a gene carrier to neural and hepatic tissue, because of 1) the presence of neural and hepatic stem-like cells, 2) the ability to cryopreserve them, 3) long-term survival in the transplanted site ...
Nanae Takahashi, Shin Enosawa, Tasuku Mitani, Hua Lu, Seiichi Suzuki, Hiroshi Amemiya, Takashi Amano, Norio Sakuragawa   +7 more
doaj   +1 more source

Mother-child bonding, environment, and motor development of babies at risk accompanied by a follow-up [PDF]

, 2021
Kellen Yamille dos Santos Chaves, Mara Marúsia Martins Sampaio Campos, Rivianny Arrais Nobre   +2 more
openalex   +1 more source

Embryo donation families : a follow-up in middle childhood [PDF]

, 2007
Couples who conceive using donated embryos rear a child to whom they are genetically unrelated. It has been suggested that this may have negative consequences for parenting and child development.
Keeley, Sarah, MacCallum, Fiona
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source