Results 121 to 130 of about 647,560 (261)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Global Stories: Child Health and Mortality Prevention Surveillance Network (CHAMPS) Program
Every year, six million children die before their 5th birthday. CDC and partners are working to answer the critical question of why. CDC\u2019s Division of High-Consequence Pathogens and Pathology (DHCPP) out of the National Center for Emerging and ...
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Protect Your Child from COVID-19, the Flu, and Other Illnesses : Help Your Child Stay Healthy at School [PDF]
Updated Apr. 27, 2023What You Need to Know\u2022 During the school year, kids tend to get sick more often \u2014 and spread germs to their friends and classmates.\u2022 COVID-19 can cause serious health problems, so it\u2019s more important than ever to ...
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Fever and its treatment among the more and less poor in Sub-Saharan Africa [PDF]
The author empirically explores the relationship between household poverty and the incidence and treatment of fever--as an indicator of malaria--among children in Sub-Saharan Africa.
Filmer, Deon
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
BMC PsychologyBackground Blood sampling is one of the invasive procedures in a hospital setting that can cause fear, anxiety, and stress in children. Aim The study aimed to determine the effect of the Liquid Motion Bubbler Timer Soothing Sensory Toy on children’s fear
Arzu Sariali̇oğlu, Tuğba Oluç
doaj +1 more source
During the last 13 years (1982-1993), The Agency for International Development (A.I.D.) through its Africa Child Survival Initiative - Combatting Childhood Communicable Diseases Project (ACSI-CCCD) has been working with African nations to strengthen ...
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