Results 111 to 120 of about 640,820 (294)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Child in Health and Disease. [PDF]
Archives of Pediatrics & Adolescent Medicine, 1953 openaire +2 more sources
Cost-Effective Prevention of Diarrheal Diseases: A Critical Review [PDF]
This paper critically reviews the existing research on the cost-effective prevention and treatment of diarrheal diseases, and identifies research priorities in this area aimed at finding ways to reduce the diarrheal disease burden.
Alix Peterson Zwane, Michael Kremer
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Acute Poisoning in Pediatric Emergency Department: A 5-Year Analysis
Cerrahpaşa Medical JournalObjective: This study aimed to delineate the etiology, clinical, and demographic characteristics of pediatric patients presenting to the emergency service with poisoning complaints and to evaluate the treatment processes retrospectively.
Ömer Osman Dağ +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
THE INFANT AND CHILD IN HEALTH AND DISEASE
AJN, American Journal of Nursing, 1940 Gertrude M. McCord +2 more
+6 more sources
Turkish Validity and Reliability of Pediatric Sleep Practices Questionnaire
Archives of Health Science and Research, 2023 Arzu SARIALIOĞLU +2 more
doaj +1 more source
, 2014 Indigenous children are over represented in areas where child safety and security are compromised, argues this report. Summary National data show that Aboriginal and Torres Strait Islander children are over-represented in various aspects of child ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source