Results 71 to 80 of about 646,168 (259)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Child Suicide: A Literature Review

Amadeus International Multidisciplinary Journal, 2017
More than one million people are practicing suicide around the world, which makes it a significant public health problem. Thus, suicide practice is one of the three most common causes of death among economically productive age groups (15-44 years), and the second cause of death in groups aged 15 to 19 years.
Thaisa Mariana Saraiva Coimbra, Thércia Lucena Grangeiro Maranhão, Raphael Rocha Freire, Miriam Delmondes Batista, Ana Cláudia De Oliveira Araújo, Célia Costa Gonçalves   +5 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nurses' contributions to good practices in child care: an integrative literature review

Revista Brasileira de Enfermagem
Objective: to identify scientific evidence on the contribution of nurses' work to good practices in child care in the Brazilian literature. Method: integrative review of the literature, carried out in Latin American and Caribbean in Health Sciences ...
Fernanda Garcia Bezerra Góes, Maria da Anunciação Silva, Geicielle Karine de Paula, Luíza Pereira Maia de Oliveira, Nathalia da Costa Mello, Sthéfany Suzana Dantas da Silveira   +5 more
doaj   +1 more source

Idiolekty pamięci – dziecięce dzienniki Zagłady. Od świadectwa do literatury

Stylistyka, 2019
This article is an attempt to characterise diaries kept by children who were witnesses or victims of the Holocaust: Renia Knoll, Rutka Laskier, Dawid Rubinowicz, Dawid Sierakowiak and Anne Frank.
Małgorzata Wójcik-Dudek
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Same anxiety, different faces: Shared mechanisms with distinct manifestations in native and non‐native speech

Brain-X
Anxiety during speech is often assumed to differ in type between native (L1) and non‐native (L2) language use. We combined continuous self‐reports with high‐resolution cardiac and electrodermal recordings in 40 Dutch–English bilingual adults who ...
Peng Wang, Lesya Ganushchak, Camille Welie, Roel vanSteensel   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Píppi, Momo, Eloíse e Grimble: apoios para se pensar a infância com ou sem tutela

Cadernos Cedes
A partir dos personagens infantis: Píppi Meialonga, Momo, Eloíse e Grimble, pretende-se discutir aspectos presentes na apresentação de tais personagens e suas infâncias narradas de forma literária.
Renata Sieiro Fernandes
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source