Results 41 to 50 of about 55,454 (257)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Humanity and Resilience: child-friendly spaces in Syria’s protracted conflict [PDF]

População e Sociedade
This paper seeks to analyse how education and child-friendly spaces impact the resilience of Syrian children affected by the protracted conflict, by ensuring humanity, dignity and protection.
Ariane Medeiros da Costa, Joana Macedo Rocha   +1 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Child Protection and Social Inequality: Understanding Child Prostitution in Malawi

Social Sciences, 2018
This article draws on empirical research to develop understandings of child prostitution, previously theorised on the basis of children’s rights, feminist, and structure/agency debates, largely ignoring children’s own understandings of their ...
Pearson Nkhoma, Helen Charnley
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Famílias e violência doméstica: condições psicossociais pós ações do conselho tutelar

Psicologia: Ciência e Profissão
O texto aborda as condições familiares implicadas em situações de risco psicossocial, focalizando o problema da violência doméstica e suas repercussões no desenvolvimento psicossocial de crianças.
Rute Grossi Milani, Sonia Regina Loureiro   +1 more
doaj   +3 more sources

Shifting Power at the Front Door: State–Community Decision-Making Partnerships in Child Protection

Social Sciences
Inequities for Indigenous people in child protection systems are well established. One avenue for addressing these inequities is at the ‘front door’ of child protection, when reports are first made to statutory child protection services.
Emily Keddell, Andrew Rudolph, Shayne Walker, Karen Hale, Jude Hughes, Jonette Chapman, William Kaipo   +6 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Child Protection In India: Examining The Need For A Centralized Agency Similar To Child Protective Services In The United States

International Journal For Multidisciplinary Research
Child protection is one of the most important responsibilities for a country. In India, the protection of children is governed through multiple legal and institutional mechanisms, including the Juvenile Justice (Care and Protection of Children) Act, 20151, Protection of Children from Sexual Offenses Act, 2012 (POCSO)2, Child Welfare Committees ...
Deepika Muthukumar, Sufiya Afrin M
openaire   +1 more source