Results 51 to 60 of about 218,247 (293)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The link between hearing impairment and child maltreatment among Aboriginal children in the Northern Territory of Australia: is there an opportunity for a public health approach in child protection?

BMC Public Health, 2020
Background International studies provide evidence of an association between child disabilities, including hearing impairment (HI), and child maltreatment.
Vincent Yaofeng He, Steven Guthridge, Jiunn-Yih Su, Damien Howard, Kylie Stothers, Amanda Leach   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Child advocacy centers: Perspectives from frontline child protection workers in Michigan, USA

Child Protection and Practice
Providing a coordinated response to child abuse among professionals from diverse fields has the potential to improve outcomes for children and advance justice in abuse cases. The multidisciplinary team model, implemented through child advocacy centers in
Nathyn A. Thompson, Kaylee R. Bares, Sarah R. Carlson   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Contact with child protection services during pregnancy: a cross-sectional study using the eLIXIR Born in South London, UK maternity-child data linkage

BMC Pregnancy and Childbirth
Background In the last decade, rates of children with child protection agency involvement have increased in many high-income countries, including the UK.
Kaat De Backer, Paul Seed, Sam Burton, Elsa Montgomery, Jane Sandall, eLIXIR-Born in South London Partnership, Abigail Easter   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Humanity and Resilience: child-friendly spaces in Syria’s protracted conflict [PDF]

População e Sociedade
This paper seeks to analyse how education and child-friendly spaces impact the resilience of Syrian children affected by the protracted conflict, by ensuring humanity, dignity and protection.
Ariane Medeiros da Costa, Joana Macedo Rocha   +1 more
doaj   +1 more source

Multi-professional work in child protection decision-making: An Israeli case study

Children and youth services review, 2019
Based on the premise that functional, multi-professional work in the child protection process is crucial to the delivery of effective service, this article reports on a qualitative study carried out to evaluate inter-agency and multi-disciplinary ...
Ravit Alfandari
semanticscholar   +1 more source