Results 81 to 90 of about 238,524 (311)
Eliminating child labour: what needs to be done?
BMJ Paediatrics Open, 2023 Ramya Subrahmanian
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Intermediaries and the International Obligation to Protect Child Witnesses in South Africa
Potchefstroom Electronic Law Journal, 2018 This contribution examines the protection of child witnesses in criminal proceedings under international and regional laws. This consideration is made against the background that the Constitution of the Republic of South Africa, 1996 proclaims in section
Rongedzayi Fambasayi, René Koraan
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Child labor, education, and children's rights [PDF]
Child labor is widespread, and bad for development, both that of the individual child, and of the society and economy in which she, or he lives. If allowed to persist to the current extent,child labor will prevent the achievement of the Millennium ...
Fares, Jean +3 more
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Your rights as a person with a disability in the child welfare system. Spanish
, 2020 Title from PDF caption (viewed on November 9, 2020)."DHS 3080 Spanish (11/2020)."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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, 2007 The toxic environment that is colonized Australia has broken many of the traditional circles of care for Indigenous children and created a service system which waits for Indigenous families to become dysfunctional before there is any response.
Muriel Bamblett +3 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Children's rights : how to promote a rights based approach in residential child care
, 2006 This paper promotes the use of children's rights in residential childcare. The 4 key principles of the UNCRC are used as tool to safeguard decision-making in Residential ChildCare.
Vrouwenfelder, Evelyn
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