Results 121 to 130 of about 2,876,234 (318)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Artificial intelligence and radiological diagnostics in hepatology
Український журнал клінічної хірургіїArtificial intelligence and radiological diagnostics in ...
M. M. Kolotilov +3 more
doaj +1 more source
Rhetoric to reality : early childhood education funding policy : a thesis in partial fulfilment of the requirements for the degree of Master of Arts in Social Policy at Massey University [PDF]
, 1999 In the 1997 budget the Government increased bulk funding to early childhood education centres by 5%. Since 1990 the amount of State spending on early childhood education has increased annually, more early childhood centres have opened and more children ...
Moss, Meg
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Research Involvement and EngagementBackground Since 2011 when the Canadian Institutes of Health Research launched the Strategy for Patient Oriented Research, there has been a growing expectation to embed patient-oriented research (POR) in the health research community in Canada.
Andrea Cross +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Childhood asthma and beyond [PDF]
, 2001 Consists of the edited transcripts of Witness Seminars organized by the History of Twentieth Century Medicine Group and held at the Wellcome Institute for the History of Medicine, London, on 4 April 2000.First published by the Wellcome Trust Centre for ...
Reynolds, LA, Tansey, EM
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Interior Finishing Study of Play Room for Early Childhood [PDF]
, 2019 The development of early childhood education facilities in the form of a playroom at the school of Early Childhood Education (PAUD) in order to provide the best facilities for the children’s growth is now increasing.
Hanom, I. (Imtihan ) +3 more
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source