Results 91 to 100 of about 6,129,228 (249)

Determinants of gonadal function after childhood cancer [PDF]

, 2014
Each year, 600–700 children are diagnosed with cancer in the Netherlands. Over the last decades, the overall long-term survival of childhood cancer has increased up to ~75%. Due to the expansion of the childhood cancer survivor population, chronic health
Dorp, W. (Wendy) van
core  

A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers

Nature Communications
The Anaplastic Lymphoma Kinase (ALK) gene is a receptor tyrosine kinase (RTK) with expression restricted to the developing nervous system. Most neuroblastomas express native ALK protein on the cell surface and ALK is uniformly overexpressed in fusion ...
Alberto D. Guerra, Smita Matkar, Christina Acholla, Colleen Casey, Grant Li, Martina Mazzeschi, Khushbu Patel, Kateryna Krytska, Chuan Chen, Skye Balyasny, Joshua Kalna, Paul Kamitsuka, Mark Gerelus, Grace Polkosnik, David Groff, Apratim Mukherje, Cynthia Adams, Gabriela Witek, Amber K. Hamilton, Daniel Martinez, Jennifer Pogoriler, Timothy T. Spear, Yimei Li, Piotr Jung, Diego Alvarado, Mattia Lauriola, John M. Maris, Adam J. Wolpaw, Kristopher R. Bosse, Dimiter Dimitrov, Mustafa Mir, Dontcho V. Jelev, Yael P. Mossé   +32 more
doaj   +1 more source

Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models

Journal for ImmunoTherapy of Cancer
Background Malignant gliomas (MGs) are the most common primary brain malignancies and are considered universally fatal. Oncolytic herpes simplex viruses (oHSVs) are promising immunotherapeutics capable of selectively lysing cancer cells, eliciting ...
Alexia K Martin, Uksha Saini, Ilse Hernandez-Aguirre, Yeaseul Kim, Kevin A Cassady, Jack Hedberg, Doyeon Kim, Ravi Dhital   +7 more
doaj   +1 more source

Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma

Nature Communications
Diffuse intrinsic pontine glioma (DIPG) is a fatal brainstem tumor desperately in need of better treatments. Chimeric antigen receptor (CAR) T cell therapies for DIPG have demonstrated clinical tolerability and bioactivity, but not universal benefit.
Edward Z. Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez, Lucy Z. Li, Sophie Jamet, Davina S. Lau, Lily I. Winter, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, Vandana Kalia, Surojit Sarkar, Michael C. Jensen, Matthew C. Biery, Nicholas A. Vitanza   +16 more
doaj   +1 more source

Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients [PDF]

, 2016
There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer diagnosis.
Ahern, JoAnn, Barakat, Lamia P., Bhatia, Smita, Bingen, Kristin M., Bondurant, Patricia G., Cohn, Susan L., Dobrozsi, Sarah K., Haugen, Maureen, Herring, Ruth Anne, Hockenberry, Marilyn, Hooke, Mary C., Landier, Wendy, Martin, Melissa, Murphy, Kathryn, Newman, Amy R., Rodgers, Cheryl C., Ruccione, Kathleen S., Sullivan, Jeneane, Weiss, Marianne E., Withycombe, Janice, Yasui, Lise   +20 more
core   +1 more source

Ethics support personnel’s perceptions of patient and parent participation in clinical ethics support services in pediatric oncology

BMC Medical Ethics
Background There is an ongoing discourse about patient and parent participation (PPP) in Clinical Ethics Support Services (CESS), and this paper focuses specifically on case-based CESS.
Isabelle Billstein, Cecilia Bartholdson, Anders Castor, Bert Molewijk, Pernilla Pergert   +4 more
doaj   +1 more source

The Cumulative Burden of Surviving Childhood Cancer: An Initial Report from the St. Jude Lifetime Cohort Study

The Lancet, 2017
Background Survivors of childhood cancer develop early and severe chronic health conditions (CHCs). A quantitative landscape of morbidity among survivors, however, has not been described.
N. Bhakta, Qi Liu, K. Ness, Malek J Baassiri, Hesham M. Eissa, F. Yeo, W. Chemaitilly, M. Ehrhardt, J. Bass, Michael W. Bishop, Kyla C Shelton, Lu Lu, Sujuan Huang, Zhenghong Li, Eric Caron, J. Lanctot, C. Howell, Timothy E Folse, V. Joshi, D. Green, D. Mulrooney, G. Armstrong, K. Krull, Tara M. Brinkman, R. Khan, D. Srivastava, M. Hudson, Y. Yasui, L. Robison   +28 more
semanticscholar   +1 more source

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia [PDF]

, 2017
Acute Myeloid Leukaemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure.
Gibson, Brenda E.S., Harrison, Christine J., Keeshan, Karen, Laing, Alison A.   +3 more
core   +1 more source

Direct oHSV Infection Induces DC Maturation and a Tumor Therapeutic Response

Viruses
Oncolytic herpes simplex virus (oHSV) is a promising cancer immunotherapy that induces tumor cell lysis and stimulates anti-tumor immunity. Our previous single-cell RNA sequencing analysis of oHSV-treated medulloblastoma tumors revealed expansion and ...
Doyeon Kim, Michael Kelly, Jack Hedberg, Alexia K. Martin, Ilse Hernandez-Aguirre, Yeaseul Kim, Lily R. Cain, Ravi Dhital, Kevin A. Cassady   +8 more
doaj   +1 more source

Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models

Scientific Reports, 2017
Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promotion of antitumor T cell responses.
Chun-Yu Chen, Pin-Yi Wang, Brian Hutzen, Les Sprague, Hayley M. Swain, Julia K. Love, Joseph R. Stanek, Louis Boon, Joe Conner, Timothy P. Cripe   +9 more
doaj   +1 more source