Results 81 to 90 of about 210,137 (310)
Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group. [PDF]
, 2020 Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted.Haeusler, Gabrielle M, Haeusler, Gabrielle M.,, Gisela Michel, Baust, Katja,, van den Oever, Selina R, Devine, KA, Koopman, Maria M, Hudson, Melissa M, Kremer, Leontien C. M., Gebauer, J, Uyttebroeck, Anne, Leontien C.M. Kremer, Uyttebroeck, A, Glaser, Adam W.,, Armenian, Saro H.,, Elvira C. van Dalen, Jordan Gilleland Marchak, Verbruggen, Lisanne C., Groll, Andreas H, van As, JW, Pavasovic, V, Claudia Kuehni, Kremer, Leontien C.M., Sung, Lillian, Elio Castagnola, Mulder, RL, Yuehan Wang, Bardi, E, Marchak, Jordan Gilleland, Tissing, W, Maeda, Miho,, Adam W. Glaser, Lisanne C. Verbruggen, Matthew J. Ehrhardt, Schulte, Fiona,, Berger, C, Devine, Katie A, Glaser, Adam W, Verbruggen, Lisanne C.,, Sato, Satomi,, Armenian, Saro H., Renée L. Mulder, den Hartogh, J, Glaser, Adam W., Kuehni, Claudia, Anne Uyttebroeck, Paul C. Nathan, Gebauer, Judith,, Gebauer, Judith, Devine, Katie A., van den Oever, Selina R., Hudson, MM, Sung, L, Schulte, Fiona, Verbruggen, LC, Berger, Claire, Nathan, Paul C., Lund University., Glaser, AW, Kepák, Tomáš,, Mulder, Renée L., Tomáš Kepák, Koopman, Maria M.W. Rianne, Ehrhardt, Matthew J., Koopman, MMW, Haupt, R, van Dalen, Elvira C., Andreas H. Groll, Roderick Skinner, van der Pal, HJH, van Dalen, Elvira C, Kato, Miho,, Langer, Thorsten, Marchak, Jordan Gilleland,, Jorrit W. van As, Langer, T, van As, Jorrit W., Kremer, Leontien C.M.,, Skinner, Roderick, Kepák, Tomáš, Monica Muraca, van As, Jorrit W, Jaap den Hartogh, den Hartogh, Jaap,, Satomi Sato, Hudson, Melissa M.,, Baust, K, Koopman, Maria M.W., Helena J.H. van der Pal, Wang, Y, Ehrhardt, Matthew J.,, Sung, Lillian,, Koopman, Maria M W Rianne, Kremer, Leontien C M, Miho Kato, Saro H. Armenian, Haeusler, GM, Castagnola, Elio,, Ehrhardt, MJ, Selina R. van den Oever, Devine, Katie A.,, van den Oever, Selina R.,, Sato, Satomi, Koopman, Maria M.W.,, Kepák, T, Tissing, Wim, Lars Hjorth, Haupt, Riccardo,, Hjorth, Lars, Kremer, LCM, Baust, Katja, Kuehni, Claudia,, Castagnola, Elio, Marchak, JG, Muraca, M, Vesna Pavasovic, Muraca, Monica,, Armenian, SH, Hjorth, L, Uyttebroeck, Anne,, Sato, S, Tissing, Wim,, Nathan, Paul C, Katie A. Devine, Ehrhardt, Matthew J, Groll, Andreas H.,, Melissa M. Hudson, Haupt, Riccardo, Kato, Miho, van den Oever, SR, Nathan, Paul C.,, Pavasovic, Vesna, van der Pal, Helena J.H., Maria M.W. (Rianne) Koopman, Kuehni, C, van der Pal, Helena J, Wang, Yuehan,, Miho Maeda, Castagnola, E, van der Pal, Helena J H, Thorsten Langer, Verbruggen, Lisanne C, Judith Gebauer, Groll, AH, van As, Jorrit W.,, Armenian, Saro H, Claire Berger, Fiona Schulte, Lillian Sung, Berger, Claire,, van der Pal, Helena J. H., van der Pal, Helena J.H.,, Michel, Gisela, den Hartogh, Jaap, Schulte, F, Hjorth, Lars,, Kato, M, Hudson, Melissa M., Wim Tissing, Riccardo Haupt, Maeda, M, Katja Baust, Haeusler, Gabrielle M., Nathan, PC, Koopman, Maria M. W. (Rianne), van Dalen, Elvira C.,, Edit Bardi, Gabrielle M. Haeusler, Mulder, Renée L.,, Maeda, Miho, van Dalen, EC, Pavasovic, Vesna,, Skinner, R, Michel, Gisela,, Skinner, Roderick,, Mulder, Renée L, Bardi, Edit, Michel, G, Wang, Yuehan, Muraca, Monica, Groll, Andreas H., Koopman, Maria M. W., Bardi, Edit, +182 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceNutritional Assessment of Childhood Cancer Survivors (the Swiss Childhood Cancer Survivor Study-Nutrition): Protocol for a Multicenter Observational Study. [PDF]
, 2019 BACKGROUND
Childhood cancer survivors are at high risk of developing adverse late health effects. Poor nutritional intake may contribute to this risk, but information about dietary intake is limited.Bochud, Murielle, Ansari Djaberi, Marc Georges, Otth, Maria, Ansari, Marc, Kuehni, Claudia Elisabeth, Belle, Fabiën Naomi, Beck Popovic, Maja +6 morecore +1 more sourceDeciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceA humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers
Nature CommunicationsThe Anaplastic Lymphoma Kinase (ALK) gene is a receptor tyrosine kinase (RTK) with expression restricted to the developing nervous system. Most neuroblastomas express native ALK protein on the cell surface and ALK is uniformly overexpressed in fusion ...Alberto D. Guerra, Smita Matkar, Christina Acholla, Colleen Casey, Grant Li, Martina Mazzeschi, Khushbu Patel, Kateryna Krytska, Chuan Chen, Skye Balyasny, Joshua Kalna, Paul Kamitsuka, Mark Gerelus, Grace Polkosnik, David Groff, Apratim Mukherje, Cynthia Adams, Gabriela Witek, Amber K. Hamilton, Daniel Martinez, Jennifer Pogoriler, Timothy T. Spear, Yimei Li, Piotr Jung, Diego Alvarado, Mattia Lauriola, John M. Maris, Adam J. Wolpaw, Kristopher R. Bosse, Dimiter Dimitrov, Mustafa Mir, Dontcho V. Jelev, Yael P. Mossé +32 moredoaj +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceEngineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma
Nature CommunicationsDiffuse intrinsic pontine glioma (DIPG) is a fatal brainstem tumor desperately in need of better treatments. Chimeric antigen receptor (CAR) T cell therapies for DIPG have demonstrated clinical tolerability and bioactivity, but not universal benefit.Edward Z. Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez, Lucy Z. Li, Sophie Jamet, Davina S. Lau, Lily I. Winter, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, Vandana Kalia, Surojit Sarkar, Michael C. Jensen, Matthew C. Biery, Nicholas A. Vitanza +16 moredoaj +1 more source
