Results 111 to 120 of about 6,129,228 (249)

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif

Blood Advances, 2019
: FOXO1 has an oncogenic role in adult germinal center–derived lymphomas, in which mutations, predominately within the AKT recognition motif, cause nuclear retention of FOXO1, resulting in increased cell proliferation.
Peixun Zhou, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, Casey Broadbent, Lewis Chaytor, Amber Whitehead, Amy Hall, Hettie O'Connor, Susan Van Noorden, Irvin Lampert, Simon Bailey, Elizabeth Molyneux, Chris M. Bacon, Simon Bomken, Vikki Rand   +18 more
doaj   +1 more source

New dual inducible cellular model to investigate temporal control of oncogenic cooperating genes

Scientific Reports
The study of cooperating genes in cancer can lead to mechanistic understanding and identifying potential therapeutic targets. To facilitate these types of studies, we developed a new dual-inducible system utilizing the tetracycline- and cumate-inducible ...
Matthew R. Kent, Amanda N. Jay, Genevieve C. Kendall   +2 more
doaj   +1 more source

P309: IMAGE-BASED HIGH-CONTENT DRUG SENSITIVITY SCREENING IDENTIFIES CONVENTIONAL, EMERGING, AND POTENTIAL NOVEL THERAPEUTIC TARGETS IN HIGH-RISK ADULT ACUTE LYMPHOBLASTIC LEUKEMIA

HemaSphere, 2022
H. Bell, M. Singh, H. Blair, A. Poll, E. Law, O. Heidenreich, F. van Delft, A. Moorman, J. Lunec, J. Irving   +9 more
doaj   +1 more source

Determinants & Sequelae of Altered Body Composition in Childhood Cancer Survivors [PDF]

, 2013
In the Netherlands, approximately 600 children are diagnosed with cancer every year. Due to improvement of treatment, combining surgery, multi-agent chemotherapy, and radiotherapy, in addition to remarkable advances in supportive care, survival has ...
Blijdorp, K. (Karin)
core  

Leaving the parental home, cohabitation, and marriage after a hematologic malignancy in childhood—A register‐based cohort study from the SALiCCS research program

Cancer Medicine
Introduction Transitioning to adulthood often involves achieving independence from the parental home. We assessed whether the likelihood of leaving the parental home, cohabitation, and marriage was similar between patients who experienced a hematologic ...
Liisa Korhonen, Hanna Mogensen, Friederike Erdmann, Maria Feychting, Line Elmerdahl Frederiksen, Elli Hirvonen, Anja Krøyer, Anniina Kyrönlahti, Nea Malila, Camilla Pedersen, Janne Pitkäniemi, Mats Talbäck, Mervi Taskinen, Jeanette Falck Winther, Laura Madanat‐Harjuoja   +14 more
doaj   +1 more source

Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing

Cell Reports: Methods
Summary: Quantitative comparison of ChIP-seq profiling between experimental conditions or samples remains technically challenging for the epigenetics field.
Alexi Tallan, Jack Kucinski, Benjamin Sunkel, Cenny Taslim, Stephanie LaHaye, Qi Liu, Jun Qi, Meng Wang, Genevieve C. Kendall, Benjamin Z. Stanton   +9 more
doaj   +1 more source

Lymphomas in Golestan province of Iran: Results of a population-based cancer registry [PDF]

, 2011
Introduction: Malignancies of lymphoid cells can be divided into Hodgkin and non-Hodgkin lymphomas (NHL) on the basis of pathologic features, clinical manifestations and treatment.
Aarabi, M., Besharat, S., Kalavi, K., Keshtkar, A., Moradi, A., Najafi, L., Noohi, A., Roshandel, G., Semnani, S.   +8 more
core  

The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patientsResearch in context

EClinicalMedicine
Summary: Background: Medulloblastoma patients with a sub-total surgical resection (STR; >1.5 cm2 primary tumour residuum post-surgery) typically receive intensified treatment.
Claire Keeling, Simon Davies, Jack Goddard, Vijay Ramaswamy, Edward C. Schwalbe, Simon Bailey, Debbie Hicks, Steven C. Clifford   +7 more
doaj   +1 more source

Targeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growth

Cell Death and Disease
High-risk neuroblastoma frequently exhibits segmental gain of chromosome 17q, including the locus of PPM1D, which encodes the phosphatase WIP1, a regulator of p53 activity, DNA repair, and apoptosis.
Diana Treis, Kristina Ihrmark Lundberg, Nicola Bell, Panagiotis Alkinoos Polychronopoulos, Conny Tümmler, Emma Åkerlund, Stefania Aliverti, Ingrid Lilienthal, Adena Pepich, Brinton Seashore-Ludlow, Kazuyasu Sakaguchi, Per Kogner, John Inge Johnsen, Malin Wickström   +13 more
doaj   +1 more source

Chronic health conditions in adult survivors of childhood cancer.

New England Journal of Medicine, 2006
K. Oeffinger, A. Mertens, C. Sklar, T. Kawashima, M. Hudson, A. Meadows, D. Friedman, N. Marina, W. Hobbie, N. Kadan-Lottick, C. Schwartz, W. Leisenring, L. Robison   +12 more
semanticscholar   +1 more source