Results 91 to 100 of about 3,851,112 (300)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Childhood leukaemia: long-term excess mortality and the proportion 'cured'. [PDF]

, 2008
Survival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general ...
Shah, A., Vincent, T., Eden, TOB, Coleman, M. P., Stiller, C. A., Eden, T. O. B., T Vincent, T O B Eden, A Shah, M G Kenward, Kenward, M. G., Stiller, CA, Coleman, MP, Shah, A, Kenward, MG, Vincent, T, C A Stiller, M P Coleman, Eden, Tim O B, Coleman, M P, Stiller, C A, Kenward, M G   +21 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Feasibility test of a UK-scalable electronic system for regular collection of patient-reported outcome measures and linkage with clinical cancer registry data: The electronic Patient-reported Outcomes from Cancer Survivors (ePOCS) system [PDF]

, 2011
Background Cancer survivors can face significant physical and psychosocial challenges; there is a need to identify and predict which survivors experience what sorts of difficulties.
Velikova, G, Amy Downing, Jones Helen, Velikova Galina, Wright Penny, Alex Newsham, Newsham, A, Penny Wright, David Forman, Downing, A, Forman David, Wright, EP, Helen Jones, Laura Ashley, Newsham Alex, Downing Amy, Ashley, L, Ashley Laura, Forman, D, Julia Brown, Brown Julia, Galina Velikova, Brown, J, Jones, H, Wright, P   +24 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Physical Activity, Fitness, and Cardiovascular Disease Risk in Adolescent Childhood Cancer Survivors Compared to Controls: The Physical Activity in Childhood Cancer Survivors Study. [PDF]

Purpose: Childhood cancer survivors have increased risk of cardiac late effects that can be potentially mitigated by physical activity and fitness. We aimed to (1) compare cardiovascular disease (CVD) risk between survivors and controls, and (2) examine ...
Bratteteig, Mari, Rueegg, Corina Silvia, Anderssen, Sigmund Alfred, Ruud, Ellen, Torsvik, Ingrid Kristin, Grydeland, May, Schindera, Christina, Raastad, Truls   +7 more
core   +1 more source

Coping and family functioning predict longitudinal psychological adaptation of siblings of childhood cancer patients [PDF]

, 2004
OBJECTIVE: To assess associations of coping and family functioning with psychosocial adjustment in siblings of pediatric cancer patients at 1, 6, 12, and 24 months after diagnosis. METHODS: Eighty-three siblings (ages 7-19 years) participated. Effects on
Caron, HN, Last, BF, Oort, F.J., Houtzager, BA, Hoekstra-Weebers, JEHM, Oort, FJ, Hoekstra-Weebers, Josette E. H. M., Oort, Frans J., Grootenhuis, MA, Grootenhuis, M.A., Last, B.F., Last, Bob F., Caron, Huib N., Houtzager, B.A., Grootenhuis, Martha A., Hoekstra-Weebers, J.E., Houtzager, Bregje A., Caron, H.N.   +17 more
core   +2 more sources

Diagnosing Preclinical Cardiac Dysfunction in Swiss Childhood Cancer Survivors: Protocol for a Single-Center Cohort Study

JMIR Research Protocols, 2020
BackgroundCardiovascular disease is the leading nonmalignant cause of late deaths in childhood cancer survivors. Cardiovascular disease and cardiac dysfunction can remain asymptomatic for many years, but eventually lead to progressive disease with high ...
Schindera, Christina, Kuehni, Claudia Elisabeth, Pavlovic, Mladen, Haegler-Laube, Eva Simona, Rhyner, Daniel, Waespe, Nicolas, Roessler, Jochen, Suter, Thomas, von der Weid, Nicolas Xavier   +8 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source