Results 111 to 120 of about 3,851,112 (300)

Risk of severe esophageal stricture among childhood cancer survivors – A population-based case-cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS)

EJC Paediatric Oncology
Purpose: Due to limited data on treatment-related risk factors associated with esophageal stricture in childhood cancer survivors, this study aimed to assess such factors in long-term survivors.
Helena K. Hansen, Peter H. Asdahl, Jane Christensen, Camilla Pedersen, Anja Krøyer, Celina S. Pontoppidan, Anna S. Holmqvist, Lars Hjorth, Thomas Wiebe, Thorgerdur Gudmundsdottir, Sofie de fine Licht, Yasmin Lassen-Ramshad, Klaus Seiersen, Morten Jørgensen, Michael RT Laursen, Hilde Øfstaas, Päivi M. Lähteenmäki, Susan A. Smith, Rebecca Howell, Catherine Rechnitzer, Henrik Hasle, Jeanette F. Winther, Line Kenborg   +22 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

The crucial role of primary care providers in the long-term follow-up of adult survivors of childhood cancer

Cancer Management and Research, 2019
Justin Jain,1 Bessi Qorri,2 Myron R Szewczuk21Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 2Department of Biomedical and Molecular ...
Jain J, Qorri B, Szewczuk MR
doaj  

Care coordination models for transition and long-term follow-up among childhood cancer survivors: a scoping review

BMJ Open
Objectives Childhood cancer survivors may experience complex health issues during transition and long-term follow-up (LTFU); therefore, high-quality healthcare is warranted. Care coordination is one of the essential concepts in advanced healthcare.
Chi Kong Li, Cho Lee Wong, Carmen Wing Han Chan, William H C Li, Ka Ming Chow, Yin Ting Cheung, Mengyue Zhang, Eden Brauer, Yongfeng Chen   +8 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Parental influence on Chinese childhood cancer survivors’ physical activity: a mixed methods study

Scientific Reports
Parents influence the physical activity (PA) of the childhood cancer survivors (CCS). This mixed-methods study, aiming to obtain an understanding of Chinese parents’ perceptions of PA in CCS and how the cancer experience changes their views, which may ...
Fengjiao Xu, Danni Lv, Jie Zhou, Zhonghai Guan, Jieni Xiong, Jingyi Yun, Xiaojun Xu, Junqing Mao, Zhipeng Shen, Libin Jin, Yunxia Liu, Haiyan Xing, Jinhu Wang, Hongmei Wang   +13 more
doaj   +1 more source

Frailty and Sleep in Adult Survivors of Childhood Cancer: A Childhood Cancer Survivor Study Report

Psycho-Oncology
ABSTRACTBackgroundYoung adult survivors of childhood cancer exhibit rates of frailty similar to adults several decades older without a cancer history. Frailty has been associated with sleep disturbances in non‐cancer populations, but the relationship has not been examined in childhood cancer survivors who are known to exhibit elevated rates of sleep ...
Lauren C. Daniel, Margaret M. Lubas, Huiqi Wang, Mariana Szklo‐Coxe, Kirsten K. Ness, AnnaLynn M. Williams, Daniel A. Mulrooney, Rebecca Howell, Wendy Leisenring, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Kevin R. Krull, Tara M. Brinkman   +14 more
openaire   +3 more sources

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Longitudinal changes of psychological distress among childhood cancer survivors: The Swiss Childhood Cancer Survivor Study. [PDF]

BACKGROUND Childhood cancer survivors may experience psychological distress due to the disease, cancer treatments, and potential late effects. Limited knowledge exists regarding longitudinal changes in psychological distress after childhood cancer. We
Kälin, Sonja, Michel, Gisela, Raguindin, Peter Francis, Rueegg, Corina S, Kuehni, Claudia E, von der Weid, Nicolas X, Bergstraesser, Eva, Tinner, Eva Maria   +7 more
core   +2 more sources