Results 31 to 40 of about 138,344 (267)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Culture in Child Education: brief reflections on a field of contested conceptions

Revista Brasileira de Educação do Campo, 2023
This article is the result of bibliographic research conducted during the specialization course in Early Childhood Education at the Universidade Federal do Norte do Tocantins, Tocantinópolis Center, whose goal was to reflect on the insertion of the ...
Thalita Melo de Souza Medeiros, Gustavo Cunha de Araújo   +1 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Family, Culture, and Challenges of Childhood (Case Study of Harandi Neighbourhood in Tehran) [PDF]

پژوهشنامه مددکاری اجتماعی
This study examines the cultural, familial, and childhood challenges faced by migrant families residing in Tehran's Harandi neighborhood. Utilizing a qualitative methodology, data were collected through semi-structured interviews with a purposive and ...
Maryam Davoodi, Mohammadrahim Safari, Alireza Ahangar, Hamideh Haditabar   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Assessing student teachers’ knowledge of English to inform curriculum design in initial teacher education

South African Journal of Childhood Education
Background: In Initial Teacher Education (ITE) programmes, there are concerns about student teachers’ English language proficiency. Aim: To discuss the first iteration of the PrimTEd English language and literacy test and analyse the results for ...
Nicky Roberts, Qetelo M. Moloi, Thelma Mort   +2 more
doaj   +1 more source

Anglophone culture, Francophone culture, family behaviours, and childhood obesity in Sudbury, Ontario

Diversity of Research in Health Journal, 2017
In general, Francophones in Ontario are more likely than their Anglophone counterparts to suffer from overweight and obesity. It has also been established that Francophones, Canada-wide, eat fewer daily servings of fruits and vegetables than Anglophones ...
Jaimie Geist, Line Tremblay, Sandra Dorman, Christina Rinaldi   +3 more
doaj   +1 more source

The Image of Childhood in Pop Culture (Childhood in Crisis)

International Journal of Linguistics, Literature and Translation, 2021
This article will focus on the importance of educational values instilled in teenage characters of the Twentieth and Twenty-first century English and American Literature. Education is a fundamental part of intellectual freedom and one of its main values is enhancing how children view, exist in, and participate in the world (Rothwell, 2013).
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source