Results 51 to 60 of about 138,344 (267)

Bridging the childhood epilepsy treatment gap in northern Nigeria (BRIDGE): Rationale and design of pre-clinical trial studies

Contemporary Clinical Trials Communications, 2019
Epilepsy is the most common serious childhood neurological disorder. In the low- and middle-income countries (LMICs) of Africa, children with epilepsy suffer increased morbidity and mortality compared to their counterparts in high-income countries, and ...
Muktar H. Aliyu, Aminu T. Abdullahi, Zubairu Iliyasu, Auwal S. Salihu, Halima Adamu, Umar Sabo, Juanita Prieto Garcia, Shehu U. Abdullahi, Aliyu Mande, Hong Xian, Hafizu M. Yakasai, Mario Schootman, Donna J. Ingles, Archana A. Patel, Abubakar Yakasai, Stacy Curry-Johnson, Usman J. Wudil, Michael R. DeBaun, Edwin Trevathan, Gretchen Birbeck, Paul Carney, Tracy Glauser, Angelina Kakooza, Phillip Pearl, Angela Wabulya, James Wheless, Jo Wilmshurst   +26 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Pendidikan Perdamaian untuk Anak Usia Dini di Tengah Budaya Kekerasan

Dunamis: Jurnal Teologi dan Pendidikan Kristiani
. This article discusses an alternative offer to deal with the culture of violence that occurs around early childhood. Therefore, early childhood slowly needs to be made aware of a culture of violence and strategies for dealing with it simply according ...
Paulus Eko Kristianto
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The impacts of culture and religious diversity on Early Childhood Development (ECD) learners a case of primary schools in Mudzi District of Mashonaland East Province, Zimbabwe

Journal of Contemporary Society Education
This study focused on the impacts of culture and religious diversity on Early Childhood Development (ECD) learners a case of primary schools in Mudzi District of Mashonaland East Province, Zimbabwe.
Ottiliah Musweweshiri
doaj   +1 more source

Childhood and Children’s Retrospective Media Consumption Experiences: The case of Norway

Nordicom Review, 2017
The focus in this article is on childhood and consumer culture with a special view on children’s media experiences retrospective. A historical perspective is applied as history provides an opportunity to reflect on changing processes within contemporary ...
Korsvold Tora
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Non-Formal Educational Institutions Provider's Readiness in the Implementation of the Regulation of the Minister of Education and Culture of the Republic of Indonesia No. 9 of 2020

Digital Press Social Sciences and Humanities, 2020
Changes in policy within the Ministry of Education and Culture of the Republic of Indonesia in 2020 manifested from the issuance of Minister of Education and Culture Regulation (Permendikbud) No. 9 of 2020.
Pamungkas, Alim Harun
doaj   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Imaginação, culturas e fontes documentais em desenhos de meninas e meninos da Educação Infantil brasileira

Studi sulla Formazione, 2014
This article presents aspects of imagination and culture of Brazilian girls and boys of Sao Paulo childhood education from some of his drawings. In dialogue with studies of sociology and anthropology it is considered that the drawings are documentary ...
Marcia Aparecida Gobbi
doaj   +1 more source