Results 41 to 50 of about 138,344 (267)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Pengenalan Budaya Dan Pembentukan Karakter Melalui Folklor Pada Anak Usia Dini

open access: yesINSANIA: Jurnal Pemikiran Alternatif Kependidikan, 2015
: Indonesia is a country rich with diversity of race, traditions, and, culture. However, this diversity is gradually shifted as to the progress of science and technology.
Winda Dwi Hudhana
doaj   +3 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Murals and Graffiti in Ruins: What Does the Art from the Aliko Hotel on Naxos Tell Us?

open access: yesArts
This manuscript investigates the cultural and educational dimensions of murals and graffiti in the ruins of the Aliko Hotel on Naxos Island. Moving beyond their aesthetic value, these artworks are examined as conduits for complex sociocultural and ...
Elzbieta Perzycka-Borowska   +3 more
doaj   +1 more source

De-Communization of Childhood. Introduction to Research on Transformations of the Discourse on Child and Childhood in Post-Communist Poland [PDF]

open access: yesFuture Human Image, 2018
The article is devoted to the phenomenon of “childhood de-communization” as a process of changing the way of childhood’s conceptualizing and social practices related to childhood during the political transformation.
Paweł Walczak
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Impact of Distance Learning on Early Childhood Development: A Meta-Analysis

open access: yesGlobal Educational Research Review
Purpose – This study evaluates the impact of distance learning on early childhood development through a meta-analysis, focusing on the effect size of various practices, identifying potential publication biases, and conducting subgroup analyses based on ...
Ahmad Syafii   +2 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Emotional distress among postpartum women in central Nepal: a cross-sectional study using structural equation modeling

open access: yesFrontiers in Global Women's Health
BackgroundPostpartum emotional distress, including depression, anxiety, and stress, is a public health concern affecting maternal well-being and child development.
Miwako Okamoto   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy