Results 31 to 40 of about 385,088 (265)

Increased serum antimicrobial peptide LL-37 and HBD-2 combined with 25-hydroxyvitamin D3 deficiency in infants with pertussis

Journal of Infection in Developing Countries, 2020
Introduction: Most children with serious infection diseases suffer from malnutrition. Vitamin D participates in the immune response through endogenous antimicrobial peptides (AMPs) regulation. The aim of this study is to investigate the expression of 25-
Sihu Chen, Wanding Ye, Weikun Zheng, Zhiwei Xu, Yiping Chen, Longteng Jin   +5 more
doaj   +1 more source

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile‐onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children

Molecular Genetics & Genomic Medicine, 2022
Background Genetic variations of neutrophil cytosolic factor 2 (NCF2), a subunit of NADPH oxidase, are usually associated with chronic granulomatous disease, and their relationship with autoimmune disorders through the defective NADPH oxidase function ...
Ivan Y. Bakutenko, Irena D. Haurylchyk, Natalia V. Nikitchenko, Elena V. Sechko, Inna A. Kozyro, Alexei M. Tchitchko, Galina M. Batyan, Alexander V. Sukalo, Nadezhda I. Ryabokon   +8 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment

Molecular Therapy: Oncolytics, 2018
Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma.
Nicholas L. Denton, Chun-Yu Chen, Brian Hutzen, Mark A. Currier, Thomas Scott, Brooke Nartker, Jennifer L. Leddon, Pin-Yi Wang, Rachelle Srinivas, Kevin A. Cassady, William F. Goins, Timothy P. Cripe   +11 more
doaj   +1 more source

CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy

Frontiers in Oncology, 2022
Antitumor activity of immune cells such as T cells and NK cells has made them auspicious therapeutic regimens for adaptive cancer immunotherapy.
Ezgi Elmas, Ezgi Elmas, Noushin Saljoughian, Noushin Saljoughian, Marcelo de Souza Fernandes Pereira, Brian P. Tullius, Kinnari Sorathia, Robin J. Nakkula, Dean A. Lee, Dean A. Lee, Meisam Naeimi Kararoudi, Meisam Naeimi Kararoudi, Meisam Naeimi Kararoudi   +12 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Identification of a murine CD45−F4/80lo HSC-derived marrow endosteal cell associated with donor stem cell engraftment

Blood Advances, 2017
: Hematopoietic stem cells (HSCs) reside in specialized microenvironments within the marrow designated as stem cell niches, which function to support HSCs at homeostasis and promote HSC engraftment after radioablation.
Kathleen M. Overholt, Satoru Otsuru, Timothy S. Olson, Adam J. Guess, Victoria M. Velazquez, Laura Desbourdes, Massimo Dominici, Edwin M. Horwitz   +7 more
doaj   +1 more source

A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells

Bio-Protocol, 2021
Functional and mechanistic studies of CD4+ T cell lineages rely on robust methods of in vitro T cell polarization. Here, we report an optimized protocol for in vitro differentiation of a mouse non-pathogenic T helper 17 (TH17) cell lineage.
Siwen Kang, Ruohan Wu, Ruoning Wang
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Bioregulation therapy in treatment of fever and hyperthermia

Лечащий Врач, 2021
Therapy of fever and hyperthermia is considered. In addition to the Federal Clinical Guidelines for the provision of emergency medical care for acute fever in children, the use of the bioregulatory drug is presented.
E. V. Konopleva
doaj