Results 51 to 60 of about 414,419 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Early life factors, childhood cognition and postal questionnaire response rate in middle age: the Aberdeen Children of the 1950s study. [PDF]

, 2005
BACKGROUND: Little is known about the relationship between early life factors and survey response in epidemiological studies of adults. METHODS: The Children of the 1950s cohort is composed of 12,150 children (boys 51.7%) born in Aberdeen 1950-56 and in ...
Heather Clark, David A Leon, Leon, David A, Morton, Susan M, Nishiwaki, Yuji, Nishiwaki Yuji, Leon David A, Clark Heather, Morton Susan M, Clark, Heather, Yuji Nishiwaki, Susan M Morton   +11 more
core   +1 more source

Identification of a murine CD45−F4/80lo HSC-derived marrow endosteal cell associated with donor stem cell engraftment

Blood Advances, 2017
: Hematopoietic stem cells (HSCs) reside in specialized microenvironments within the marrow designated as stem cell niches, which function to support HSCs at homeostasis and promote HSC engraftment after radioablation.
Kathleen M. Overholt, Satoru Otsuru, Timothy S. Olson, Adam J. Guess, Victoria M. Velazquez, Laura Desbourdes, Massimo Dominici, Edwin M. Horwitz   +7 more
doaj   +1 more source

A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells

Bio-Protocol, 2021
Functional and mechanistic studies of CD4+ T cell lineages rely on robust methods of in vitro T cell polarization. Here, we report an optimized protocol for in vitro differentiation of a mouse non-pathogenic T helper 17 (TH17) cell lineage.
Siwen Kang, Ruohan Wu, Ruoning Wang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

National partnership agreement on Indigenous early childhood development [PDF]

, 2015
Summary This second report on the health indicators in the National Partnership Agreement on Indigenous Early Childhood Development finds areas of improvement as well as areas of concern in the health of Aboriginal and Torres Strait Islander children ...
Australian Institute of Health and Welfare
core  

Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis [PDF]

, 2011
<p><b>Background:</b> Grip strength, walking speed, chair rising and standing balance time are objective measures of physical capability that characterise current health and predict survival in older populations. Socioeconomic position (
Sung-il Cho, Rachel Cooper, Kate Birnie, Noronha Kenya, Beatriz E. Alvarado, Ebrahim, S, Steptoe, A., Osler, M., HALCyon study team,, Tynelius, Per, Weir, D., Yoav Ben-Shlomo, Ebrahim, Shah, Tomas Hemmingsson, Syddall Holly, Corley, Janie, Cooper Cyrus, Martin, RM, Christensen Kaare, Alberto Palloni, Richard M. Martin, Zunzunegui, Maria Victoria, Demakakos Panayotes, Steptoe, A, Sayer Avan Aihie, Sayer, A., HALCyon study team, null null, Hemmingsson Tomas, Leone Craig, Gallacher, John Edward, Sayer, AA, Osler Merete, Antony Bayer, Whalley Lawrence J., Bayer, A, Alvarado, BE, Bayer, A., Jang, S.N., Birnie Kate, Inskip Hazel, Steven Haas, Ebrahim, S., Zunzunegui, M.V., Osler, M, Kuh, Diana, Christensen, Kaare; id_orcid, Brigitte Santos-Eggimann, Gow, Alan J, Gow Alan J., Deary, Ian J, Panayotes Demakakos, Martin Richard M., Richard M Martin, Gow, AJ, Cooper, C., Diana Kuh, Gallacher John, Birnie, K., Merete Osler, Martin, R.M., Rasmussen, F, Craig, L., Janie Corley, Kuh Diana, Gallacher, John, Birnie, K, Gunnell, D, Kuh, Dianna, Gow, A., Per Tynelius, Shah Ebrahim, Spagnoli, J, Cooper, R., Martin, Richard M, Bayer, Antony, Cyrus Cooper, Tynelius, P., SANOS-EGGIMANN, B, ALVARADO, B, Gow, Alan J.; id_orcid, Christensen, Kaare, Noronha, K, Syddall, H, Rasmussen Finn, Alan J Gow, ?, ?, Christensen, K, Avan Aihie Sayer, Haas, S., Deary, IJ, DEARY, I, Alvarado, Beatriz E, Beatriz E Alvarado, Rebecca Hardy, Hardy Rebecca, Cho, S.I., Gow, Alan J., Inskip, H, Cho Sung-il, David Weir, SAYER, A, Whalley, L.J., Demakakos, P, Haas Steven, Kuh, D, Corley, J., Hemmingsson, T, Noronha, K., Santos-Eggimann, B., Alvarado, Beatriz E., Craig, L, CHO, S, Deary, I.J., Hardy, R, MARTIN, R, Cooper, R, Whalley, LJ, Gunnell, David, Holly Syddall, Spagnoli Jacques, Bayer Antony, Noronha, Kenya, Gow, A.J., Zunzunegui Maria Victoria, Corley Janie, Starr John, Kuh, D., Hemmingsson, Tomas, Santos-Eggimann Brigitte, ZUNZUNEGUI, M, Hardy, R., Kaare Christensen, Craig Leone, Steptoe Andrew, Syddall, H., Whalley, Lawrence J, Palloni Alberto, Zunzunegui, MV, Inskip, Hazel, Birnie, Kate, Corley, J, Ben-Shlomo, Yoav, Tynelius Per, Starr, J, Haas, Steven, Spagnoli, J., Hazel Inskip, Ian J Deary, Gow, Alan John, Gallacher, J., Lawrence J Whalley, Santos-Eggimann, Brigitte, Syddall, Holly, Christensen, K., Andrew Steptoe, Osler, Merete, Ben-Shlomo, Y., Deary Ian J., Jang Soong-nang, Bayer, Antony James, Cooper, C, WHALLEY, L, Hemmingsson, T., Starr, J., David Gunnell, Rasmussen, Finn, Cho, Sung-il, Craig, Leone, Gunnell David, Sayer, Avan Aihie., SYDALL, H, John Gallacher, Soong-nang Jang, Jang, S-N., Ben-Shlomo, Y, Palloni, A, Sayer, A.A., Haas, S, Hardy, Rebecca, Palloni, Alberto, Demakakos, Panayotes, Maria Victoria Zunzunegui, Inskip, H., Cooper, Rachel, Alan J. Gow, John Starr, Gunnell, D., Cooper Rachel, Cho, SI, Ian J. Deary, Finn Rasmussen, Deary, Ian J., Santos-Eggimann, B, Martin, Richard M., Weir, David, Weir, D, JANG, S, Rasmussen, F., Cho, S., Cooper, Cyrus, Weir David, Jang, SN, GOW, A, Alvarado, B.E., Spagnoli, Jacques, Sayer, Avan Aihie, Jang, Soong-nang, Gallacher, J, Demakakos, P., HALcyon study team, ., Lawrence J. Whalley, Alvarado Beatriz E., Palloni, A., Tynelius, P, Steptoe, Andrew, Kenya Noronha, Whalley, Lawrence J., Ben-Shlomo Yoav, Starr, John, Jacques Spagnoli, PALLINI, A, Ebrahim Shah   +222 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

TGF-β Inhibition Improves Oncolytic Herpes Viroimmunotherapy in Murine Models of Rhabdomyosarcoma

Molecular Therapy: Oncolytics, 2017
Oncolytic viruses are an emerging class of cancer therapeutics that couple cytotoxicity with the induction of an anti-tumor immune response. Host-virus interactions are complex and modulated by a tumor microenvironment whose immunosuppressive activities ...
Brian Hutzen, Chun-Yu Chen, Pin-Yi Wang, Les Sprague, Hayley M. Swain, Julia Love, Joe Conner, Louis Boon, Timothy P. Cripe   +8 more
doaj   +1 more source

DONKIN, DISEASES OF CHILDHOOD [PDF]

Annals of Surgery, 1894
n ...
openaire   +1 more source