Results 61 to 70 of about 414,419 (312)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

New Methodology for Estimating the Burden of Infectious Diseases in Europe [PDF]

, 2012
Kretzschmar M, Mangen M-JEJ, Pinheiro JP, et al. New Methodology for Estimating the Burden of Infectious Diseases in Europe. PLoS Medicine.
consortium, BCoDE, Fevre, Eric M., Lai Taavi, Claudia Stein, Mangen, MJ, Dep IRAS, FRANCO, ELISABETTA, Fevre, E.M., Kretzschmar, Mirjam, BCoDE consortium, Piotr Kramarz, Havelaar Arie H., Stein Claudia, Mangen, M, Pinheiro, P, Paulo Pinheiro, Beate Jahn, Mangen Marie-Josée J., Havelaar, AH, Cassini, Alessandro, Fèvre Eric M., Havelaar, A, Pinheiro, Paulo, Fevre, Eric, Longhi, Silvia, Havelaar, Arie H, Lai, Taavi, Fèvre, Eric M, Stein, C, Mangen, Marie-Josée J, Longhi, S, Beate Jahn (170765), Mirjam Kretzschmar, Mirjam Kretzschmar (27309), ?, ?, Longhi Silvia, Fèvre, EM, Mangen, M.J.J., Stein, C., Mangen, Marie-Josee E. J., Stein, C,, Cassini Alessandro, Eric M. Fèvre (125784), Pinheiro, Joao Paulo, Mangen, M.J., Pinheiro Paulo, Arie H. Havelaar (170779), Alessandro Cassini (170788), Risk Assessment of Toxic and Immunomodulatory Agents, Taavi Lai, Havelaar, A.H., Kramarz, Piotr, Arie H Havelaar, Kretzschmar Mirjam, Jahn, B., Cassini, A., BCoDE consortium, x, Lai, T, Kramarz, P, Piotr Kramarz (170792), Stein, Claudia, Kramarz Piotr, Jahn, Beate, Fèvre, E, Cassini, A, Marie-Josée J Mangen, Marie-Josée J. Mangen (170760), Havelaar, Arie H., Kretzschmar, M.E.E., Pinheiro, P., Silvia Longhi (170771), Jahn, B, Eric M Fèvre, Ricciardi, Gualtiero, Kretzschmar, M., Paulo Pinheiro (170764), Jahn Beate, Franco, E, Lai, T., Kramarz, P., Alessandro Cassini, Longhi, S., Taavi Lai (170775), Claudia Stein (170785), Silvia Longhi, Kretzschmar, M   +85 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Childhood Ataxia with Central Nervous System Hypomyelination / Vanishing White Matter [PDF]

, 2012
Clinical characteristics Childhood ataxia with central nervous system hypomyelination / vanishing white matter (CACH/VWM) is characterized by ataxia, spasticity, and variable optic atrophy.
van der Knaap, M.S., Pagon, R.A., Schiffmann, R., Dolan, C.R., Stephens, K., Adam, M.P., Bird, T.D., Fogli, A., Boespflug-Tanguy, O.   +8 more
core  

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

Cell Reports, 2016
The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-
Yohei Niikura, Risa Kitagawa, Katsumi Kitagawa   +2 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Infection Can’t be Hidden in a Pocket

Zdorovʹe Rebenka, 2012
The article deals with key aspects of infectious processes; brief description of cyclic, noncyclic and multi infectious processes that occur in the human body is given.
I.V. Bogadelnikov, Ye.A. Kruger, A.V. Bobryshevа, G.I. Smirnov   +3 more
doaj   +1 more source

Hodgkin’s Disease in Childhood [PDF]

Blood, 1973
Abstract Thirty-eight children with Hodgkin’s disease have been treated over the past 8 yr with either intensive radiotherapy or combination chemotherapy (MOPP), depending on their initial stage. The median survival of the entire group of children has not yet been reached, as 63% are still alive, but it will be in excess of 58 mo. Median
R C, Young, V T, DeVita, R E, Johnson
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source