Results 41 to 50 of about 414,419 (312)

Tetramethylpyrazine potentiates arsenic trioxide activity against HL-60 cell lines

Brazilian Journal of Medical and Biological Research, 2012
The objective of this study was to evaluate the effects of tetramethylpyrazine (TMP) in combination with arsenic trioxide (As2O3) on the proliferation and differentiation of HL-60 cells.
Yuni Wu, Youhua Xu, Yali Shen, Cuicui Wang, Gaili Guo, Tiantian Hu   +5 more
doaj  

Current View of Hemorrhagic Fever with Renal Syndrome in Adults and Children: an Overview

Güncel Pediatri
The review is devoted to hemorrhagic fever with renal syndrome (HFRS), analyzing studies on pathogenesis, etiology, diagnosis and treatment. The results of clinical features of the disease manifestation in children, as well as preventive measures aimed ...
Ilnur I Yagudin, Svetlana N Naidenkina, Margarita K Ermakova, Darya O Yagudina   +3 more
doaj   +1 more source

Viburcol — Bioregulatory Approach in Childhood Diseases

Zdorovʹe Rebenka, 2015
One of the most urgent problems of modern pediatrics and neonatology is a need for drugs, which, along with proven efficacy, also will have maximal safety for a growing child’s body.
S.V. Popovich
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Bioregulation therapy in treatment of fever and hyperthermia

Лечащий Врач, 2021
Therapy of fever and hyperthermia is considered. In addition to the Federal Clinical Guidelines for the provision of emergency medical care for acute fever in children, the use of the bioregulatory drug is presented.
E. V. Konopleva
doaj  

Increased serum antimicrobial peptide LL-37 and HBD-2 combined with 25-hydroxyvitamin D3 deficiency in infants with pertussis

Journal of Infection in Developing Countries, 2020
Introduction: Most children with serious infection diseases suffer from malnutrition. Vitamin D participates in the immune response through endogenous antimicrobial peptides (AMPs) regulation. The aim of this study is to investigate the expression of 25-
Sihu Chen, Wanding Ye, Weikun Zheng, Zhiwei Xu, Yiping Chen, Longteng Jin   +5 more
doaj   +1 more source

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile‐onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children

Molecular Genetics & Genomic Medicine, 2022
Background Genetic variations of neutrophil cytosolic factor 2 (NCF2), a subunit of NADPH oxidase, are usually associated with chronic granulomatous disease, and their relationship with autoimmune disorders through the defective NADPH oxidase function ...
Ivan Y. Bakutenko, Irena D. Haurylchyk, Natalia V. Nikitchenko, Elena V. Sechko, Inna A. Kozyro, Alexei M. Tchitchko, Galina M. Batyan, Alexander V. Sukalo, Nadezhda I. Ryabokon   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rule-based models of the interplay between genetic and environmental factors in childhood allergy [PDF]

, 2013
Both genetic and environmental factors are important for the development of allergic diseases. However, a detailed understanding of how such factors act together is lacking. To elucidate the interplay between genetic and environmental factors in allergic
Erik Melén (276082), van Hage, Marianne, Sääf Annika, Pershagen Göran, Ville Pulkkinen (397765), Komorowski Jan, Cilla Söderhäll (117617), Göran Pershagen, Jan Komorowski, Nathalie Acevedo (147971), Torabi Moghadam, Behrooz, Juha Kere, Marianne van Hage (91132), Kabesch Michael, Jan Komorowski (80237), Torabi Moghadam Behrooz, Behrooz Torabi Moghadam, Pietras, Christina Orsmark, Moghadam, Behrooz Torabi,, Orsmark Pietras, Christina, Gert Doekes (397763), Kere Juha, Kere, Juha, Markus Ege, Pulkkinen, Ville, Cilla Söderhäll, van Hage Marianne, Moghadam, Behrooz Torabi, Braun-Fahrlaender, Charlotte, Michael Kabesch, Markus Ege (487113), Melén Erik, Komorowski, Jan,, Behrooz Torabi Moghadam (487112), Annika Scheynius, Kabesch, Michael, Riedler, Josef, Göran Pershagen (147977), Bornelöv Susanne, Pulkkinen Ville, Braun-Fahrländer Charlotte, Braun-Fahrländer, Charlotte, Christina Orsmark Pietras, Acevedo Nathalie, Anna Bergström (276081), Ege, Markus, Ville Pulkkinen, Nathalie Acevedo, Bergström, Anna, Melén, Erik, Komorowski, Jan, Erik Melén, Christina Orsmark Pietras (397760), Ege Markus, Riedler Josef, Susanne Bornelöv (189128), Bornelöv, Susanne, Pershagen, Göran, Sääf, Annika, Doekes, Gert, Susanne Bornelöv, Gert Doekes, Orsmark Pietras Christina, Söderhäll Cilla, Josef Riedler, Annika Sääf, Charlotte Braun-Fahrländer, Anna Bergström, Acevedo, Nathalie, Annika Sääf (31948), Söderhäll, Cilla, Doekes Gert, Bornelöv, Susanne,, Scheynius, Annika, Annika Scheynius (31954), Charlotte Braun-Fahrländer (18248), Josef Riedler (194501), Juha Kere (11900), Bergström Anna, Scheynius Annika, Marianne van Hage, Michael Kabesch (185885)   +81 more
core   +1 more source

CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy

Frontiers in Oncology, 2022
Antitumor activity of immune cells such as T cells and NK cells has made them auspicious therapeutic regimens for adaptive cancer immunotherapy.
Ezgi Elmas, Ezgi Elmas, Noushin Saljoughian, Noushin Saljoughian, Marcelo de Souza Fernandes Pereira, Brian P. Tullius, Kinnari Sorathia, Robin J. Nakkula, Dean A. Lee, Dean A. Lee, Meisam Naeimi Kararoudi, Meisam Naeimi Kararoudi, Meisam Naeimi Kararoudi   +12 more
doaj   +1 more source