Results 71 to 80 of about 1,305,310 (255)

No particularly negative impact of the Covid-19 pandemic on the mental health of individuals with higher levels of childhood trauma

Frontiers in Psychiatry
BackgroundInitial studies suggest that individuals with a history of traumatic life experiences, particularly childhood trauma, may be more susceptible to increased mental health problems in the wake of the COVID-19 pandemic.MethodsThe present cross ...
Elisabeth M. Weiss, Andreas Fink, Ilona Papousek, Silvia Exenberger-Vanham, Astrid Lampe, Verena Dresen, Markus Canazei   +6 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Another step closer to measuring the ghosts in the nursery: preliminary validation of the Trauma Reflective Functioning Scale [PDF]

, 2014
The aim of this study was to examine preliminary evidence of the validity of the Trauma Reflective Functioning Scale and to investigate reflective functioning (RF) and attachment in pregnant women with histories of trauma, with a particular focus on the ...
Berthelot, N, Fonagy, P, Odette eBernazzani, Peter eFonagy, Normandin, L, Nicolas eBerthelot, Karin eEnsink, Nicolas Berthelot, Ensink, K, Peter Fonagy, Lina Normandin, Bernazzani, O, Lina eNormandin, Karin Ensink, Odette Bernazzani   +14 more
core   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

The impact of childhood trauma on emotional distress and the moderating role of sense of coherence among college students in China

Scientific Reports
Childhood trauma is strongly linked to emotional distress. However, few studies have explored the impact of sense of coherence (SOC) on the relationship between childhood trauma and emotional distress in college students.
Ningdan Fan, Huanhuan Fan, Ruiqing Luo, Yu Wang, Yushun Yan, Xiao Yang, Min Wang, Yikai Dou, Rongjun Ni, Jinxue Wei, Wanqiu Yang, Xiaohong Ma   +11 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Refugees, trauma and adversity-activated development [PDF]

, 2007
The nature of the refugee phenomenon is examined and the position of mental health professionals is located in relation to it. The various uses of the word 'trauma' are explored and its application to the refugee context is examined.
Papadopoulos, Renos
core   +1 more source

Childhood trauma and personal mastery: their influence on emotional reactivity to everyday events in a community sample of middle-aged adults.

PLoS ONE, 2015
Childhood trauma is associated with premature declines in health in midlife and old age. Pathways that have been implicated, but less studied include social-emotional regulation, biological programming, and habitual patterns of thought and action.
Frank J Infurna, Crystal T Rivers, John Reich, Alex J Zautra   +3 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

The relationship of childhood bullying and paranoid thinking in a clinical population: the role of mediators

, 2012
A wealth of research evidence has been accumulating over the last two decades, highlighting the association of childhood trauma and psychosis. However, research has focused more on investigating the prevalence of childhood trauma in individuals with ...
Chaudhry, Khadija
core   +1 more source