Results 61 to 70 of about 1,616,946 (349)

Neurocognitive deficits in HIV-infected women and victims of childhood trauma

, 2012
ArticleThe study investigated the behavioral and brain effects of childhood trauma and human immunodeficiency virus (HIV) infection, both separately and in combination, and assessed potential interactions in women who were dually affected.
Spies G., Cherner M., Archibald S.L., Fennema-Notestine C., Seedat S.   +4 more
core   +1 more source

Refugees, trauma and adversity-activated development [PDF]

, 2007
The nature of the refugee phenomenon is examined and the position of mental health professionals is located in relation to it. The various uses of the word 'trauma' are explored and its application to the refugee context is examined.
Papadopoulos, Renos
core   +1 more source

Multidirectional Pathways between Attachment, Mentalizing, and Posttraumatic Stress Symptomatology in the Context of Childhood Trauma

Psychopathology, 2020
Introduction:Exposure to traumatic stressful events in childhood is an important risk factor for the development of posttraumatic symptomatology. From a mentalization-based developmental perspective, childhood adversity can affect attachment in children ...
Yu Lien Huang, P. Fonagy, J. Feigenbaum, P. R. Montague, T. Nolte   +4 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of childhood sexual abuse on the outcome of intensive trauma-focused treatment for PTSD [PDF]

, 2018
Background: It is assumed that PTSD patients with a history of childhood sexual abuse benefit less from trauma-focused treatment than those without such a history.
Minnen, A. van, Van Minnen, A., De Jongh, A., Anouk Wagenmans, Sleijpen, M., Trauma and Grief, de Jongh, Ad, Wagenmans, A., Marieke Sleijpen, Agnes Van Minnen, Sleijpen, M.J.T., Jongh, A. de, Leerstoel Boelen, Ad De Jongh   +13 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression.

PLoS ONE
Within mindfulness-based programs (MBPs), mixed results have been found for the role of childhood trauma as a moderator of depression outcomes. Furthermore, childhood trauma and PTSD symptoms have been identified as possible risk factors for the ...
Nicholas K Canby, Elizabeth A Cosby, Roman Palitsky, Deanna M Kaplan, Josie Lee, Golnoosh Mahdavi, Adrian A Lopez, Roberta E Goldman, Kristina Eichel, Jared R Lindahl, Willoughby B Britton   +10 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Childhood trauma, proactive coping, and borderline personality among adults [PDF]

, 2019
Research on the factors causing borderline personality (BP) has not been done although Indonesian adults are showing several behaviors classified under BP criteria.
Wibhowo, Christine, Retnowati, Sofia, Hasanat, Nida Ul   +2 more
core