Results 71 to 80 of about 144,397 (198)

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

open access: yesAdvanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan   +12 more
wiley   +1 more source

Digital Home Learning Activities in Early Childhood: Associations with Socio-Emotional Difficulties

open access: yesBehavioral Sciences
Families play a central role in shaping young children’s learning and development through everyday interactions and shared activities in the home environment. As digital technologies have become increasingly embedded in family life, digital home learning
Katerina Krousorati   +2 more
doaj   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

open access: yesAdvanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty   +4 more
wiley   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao   +12 more
wiley   +1 more source

A Case Study of Chinese Children’s Biliteracy Learning at Home and School

open access: yesCanadian Journal for New Scholars in Education, 2016
Canada is a multicultural and multilingual country with a large number of immigrants. It is therefore not unusual to see a highly diverse student population in Canadian elementary schools.
Xiaoxiao Du
doaj  

Parental Mindset and SES: Mitigating Income–Vocabulary Gap in Early Childhood of Emergent Bilinguals

open access: yesEducation Sciences
In addition to being influenced by structural factors like socioeconomic background (SES), children’s achievements are also influenced by psychological factors like the parental mindset.
Huilin Luo, Jialin Lai, Jing Zhao
doaj   +1 more source

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