Results 41 to 50 of about 8,464,968 (354)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

THE EMPOWERMENT OF CHILDREN IN EDITH NESBIT’S THE RAILWAY CHILDREN

open access: yesEnglish Review: Journal of English Education, 2016
This research is aimed at describing the empowerment of children in Edith Nesbit’s The Railway Children. The problems formulated in the research will be answered in the descriptions consisting of thoughts, actions, and feelings of the main characters in ...
Adam Anshori
doaj  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

How does children's literature portray global perspectives?

open access: yesJournal of Global Education and Research, 2022
The need for global education is increasing in this global era, and children's literature becomes an essential resource to address this need. However, there is little research on how global perspectives are depicted in children's literature. The current study fills the gap in our understanding by examining contemporary children's picture books that ...
openaire   +4 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Call Me By My Name

open access: yesBarnboken: Tidskrift för Barnlitteraturforskning
This article investigates naming practices in Italian postcolonial children’s literature. I define naming practices as a series of verbal figures that display affirmation of one’s own name. While multilingualism in children’s fiction has recently gained
Anna Finozzi
doaj   +1 more source

Folklore and Children’s Literature: A Content Analysis of the de Grummond Children’s Literature Collection

open access: yesSLIS Connecting, 2015
Folklore can be defined as “context, performance, attitude, cultural tastes, and the like†(Toelken, 1996, p.7). With folktale and fairy tales, these stories embody cultural values and morals, aiding in learning a lesson or to keep intact a cultural tradition.
openaire   +4 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Successes, challenges, and surprises: teacher reflections on using children’s literature to examine complex social issues in the elementary classroom

open access: yesTeachers and Teaching, 2022
Children’s literature provides elementary teachers and students the opportunity to critically engage in the world around them. However, too often teachers choose not to engage students in discussions of complex social issues out of a sense of fear or discomfort.
Andrea M. Hawkman   +3 more
openaire   +2 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

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