Results 71 to 80 of about 540,140 (284)

Towards the Amplification of Children’s Rights within Olympic Discourses

Eracle
The intersection of Mega-Sport Events (MSEs) and human rights has given rise to considerable academic commentary over the last number of years. However, within this literature, the treatment of, and engagement with, children’s rights law, has been ...
Seamus Byrne
doaj   +3 more sources

Child-Right-ing: Going Beyond Innocence to Realize the Rights of Undocumented Migrant Children through Struggles for the Rights of All Children

Nordic Journal of Migration Research
Children’s rights are a blessing and a curse for undocumented migrant children. They are one of few available resources in migrant struggles, but at the same time they are also extensively mobilized to govern children’s mobility. In this article, I first
Jacob Lind
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Allt eller inget? Barns rättigheter i lärarutbildning

Utbildning & Demokrati, 2020
In 2020, the United Nations Convention on the Rights of the Child (UNCRC) is incorporated into Swedish law. In the proposals for new legislation, capacity building was emphasized to generally develop knowledge about children’s rights among professionals ...
Åsa Olsson, Helene Elvstrand, Nina Thelander   +1 more
doaj   +1 more source

How Procreation Generates Parental Rights and Obligations [PDF]

, 2017
Philosophical defenses of parents’ rights typically appeal to the interests of parents, the interests of children, or some combination of these. Here I propose that at least in the case of biological, non-adoptive parents, these rights have a different ...
Cholbi, Michael
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Theorising children’s participation: Trans-disciplinary perspectives from South Africa

Perspectives in Education, 2011
From text: Children’s participation is a popular rallying cry among child rights activists and community development groups, backed by the recognition of children’s participatory rights in the United Nations Convention on the Rights of the Child (UNCRC).
Patricia Henderson, Shirley Pendlebury, E. Kay M. Tisdall   +2 more
doaj   +3 more sources

Empowering and Promoting Children’s Rights by Implementing Skills Labs Using Engaging Learning Activities

Societies
Despite the efforts to advance children’s rights’ protection, many children’s rights are still not respected in many places. This makes it more necessary than ever to raise the awareness of children’s rights and prepare new generations of students to ...
Charikleia Pitsou, Ioannis G. Katsantonis, Argyrios Katsantonis, Georgios S. Gorozidis   +3 more
doaj   +1 more source

Protecting migrant children’s rights [PDF]

, 2017
This report relates to the training workshop on the protection of migrant children’s rights which is part of an ESRC-funded research project currently led by Dr Ana Beduschi (https://migrantchildren.org/).
Beduschi, AC, Patsianta, K
core