Results 71 to 80 of about 13,950,912 (413)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Language and Reading Progress of Young Deaf and Hard-of-Hearing Children. [PDF]

, 2020
We examined the language and reading progress of 336 young DHH children in kindergarten, first and second grades. Trained assessors tested children's language, reading, and spoken and fingerspelled phonological awareness in the fall and spring of the ...
Antia, Shirin D, Branum-Martin, Lee, Connor, Carol M, Easterbrooks, Susan, Lederberg, Amy R, Schick, Brenda, Webb, Mi-Young   +6 more
core  

Error analysis of expressive analogy task in Spanish-English bilingual school age children with and without specific language impairment [PDF]

, 2015
textPurpose: The relational shift hypothesis (RSH) states that, as children age, the way in which they interpret analogies shifts from a focus on object similarities to relational aspects of objects.
Moreno, Beverly
core   +1 more source

Influence of histone deacetylase inhibitors and DNA-methyltransferase inhibitors on the NK cell-mediated lysis of pediatric B-lineage leukemia.

Frontiers in Oncology, 2013
Epigenetic drugs like histone deacetylase inhibitors and DNA methyltransferase inhibitors have been shown to be effective against a variety of tumor entities.
Matthias Manuel Pfeiffer, Helen eBurrow, Sabine eSchleicher, Rupert eHandgretinger, Peter eLang   +4 more
doaj   +1 more source

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012

Morbidity and mortality weekly report. Surveillance summaries, 2018
Problem/Condition Autism spectrum disorder (ASD). Period Covered 2012. Description of System The Autism and Developmental Disabilities Monitoring (ADDM) Network is an active surveillance system that provides estimates of the prevalence and ...
D. Christensen, K. V. N. Braun, J. Baio, D. Bilder, Jane M. Charles, J. Constantino, J. Daniels, M. Durkin, Robert T. Fitzgerald, M. Kurzius-Spencer, L. Lee, S. Pettygrove, C. Robinson, E. Schulz, Chris S. Wells, M. Wingate, W. Zahorodny, M. Yeargin-Allsopp   +17 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Writing a Children Story Book: Rosaline the Beautiful Rose [PDF]

, 2016
This project brings up an issue about beauty concept in a form of children's story book with fantasy genre for children at the ages of 12 to 15. The story shows some beauty concepts in the world through the main character's fantastical adventure.
Irawan, S. (Stefanny), Lunardi, J. (Josephine)   +1 more
core  

The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis

Arthritis Research & Therapy
Background Facet joint osteoarthritis (OA) is prevalent in patients with adolescent idiopathic scoliosis (AIS). The most pronounced OA presents above and below the curve's apex where the intervertebral rotation is the greatest.
Kai Sheng, Daniel G. Bisson, Neil Saran, Jake Bourdages, Christopher Coluni, Kirby Upshaw, Kerstin Tiedemann, Svetlana V. Komarova, Jean A. Ouellet, Lisbet Haglund   +9 more
doaj   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Guidelines for library service for young adults

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2001
Directrius per a la planificació i avaluació de serveis adreçats a adolescents en biblioteques ...
IFLA. Section of Library for Children and Young Adults
doaj