Results 61 to 70 of about 1,112,929 (217)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Scottish Journal of Residential Child Care, 2014 This PhD project aims to develop the theoretical and practical understanding of historic abuse by exploring the concepts of forgiveness and transitional justice and studying how these can be applied to the processes and interventions in responding to ...
S. Karim, A. Kendrick
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The home office children's department: implementing the 1948 Children's Act, 1950-1970
Scottish Journal of Residential Child CareIt is now little remembered that the UK’s Home Office was once responsible for overseeing the state care of children in England and Wales. During the 1950s and 1960s, the Home Office children’s department issued a series of detailed reports that ...
Jim Goddard
doaj +1 more source
International Journal of Social Pedagogy, 2013 A reassertion of the value of relationships in UK practice with children in care is underway after a period when outcome focused work obscured their importance.
doaj +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The best PEEP or the optimal PEEP or the piece PEEP of the mechanical power puzzle?
Critical Care, 2022 George Briassoulis +2 more
doaj +1 more source
In Vivo Analysis of Tissue S-Nitrosothiols in Pediatric Sepsis
AntioxidantsS-nitrosothiols are endogenous, bioactive molecules. S-nitrosothiols are implicated in many diseases, including sepsis. It is currently cumbersome to measure S-nitrosothiols clinically.
Daniel T. Cater +3 more
doaj +1 more source