Advanced Science, EarlyView.An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang +15 more
wiley +1 more source
The effect of acceptance and commitment therapy on depression in parents of children with special needs: a meta-analysis. [PDF]
Front PsycholWang W, He H.
europepmc +1 more source
Advanced Science, EarlyView.scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong +6 more
wiley +1 more source
Correlation Between Oral Health Status and Oral Health Impact Profile in Children With Special Needs: A Cross-Sectional Study. [PDF]
CureusAggarwal S +7 more
europepmc +1 more source
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
Contextual factors experienced by mothers of children with special needs. [PDF]
S Afr J PhysiotherMatambanadzo P, Rhoda AJ.
europepmc +1 more source
Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants
Advanced Science, EarlyView.A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr +6 more
wiley +1 more source
The effect of cognitive behavioral therapy on depressive symptoms in parents of children with special needs: a systematic review and meta-analysis of randomized controlled trials. [PDF]
Syst RevGuo Y, Lan J, He H.
europepmc +1 more source
Advanced Science, EarlyView.Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi +9 more
wiley +1 more source
Parent-Implemented Interventions for Children with Special Needs in Türkiye: An Analysis of Single-Subject Research Studies. [PDF]
Behav Sci (Basel)Sönmez N, Alptekin S.
europepmc +1 more source