Results 111 to 120 of about 940,909 (306)

Experiencias y estrategias de mujeres en STEM en cargos de liderazgo e híbridos en el sector TI

open access: yes360, 2022
Los estereotipos de género representan un importante factor en la elección vocacional de las mujeres en Chile. Esto ha sido especialmente evidente en las carreras STEM, históricamente masculinizadas.
Rosa Martínez Gómez   +3 more
doaj  

Structural Volatility in Chile: A Policy Report [PDF]

open access: yes
This paper identifies Chile`s economic weaknesses and offers policy recommendations for increasing stability. Current problems include weak international financial links, a Central Bank mandate that is ill-designed to deal with terms of trade shocks, a ...
Ricardo J. Caballero
core  

Divergent Regulatory Effects of Jasmonic Acid on Tomato Lycopene Biosynthesis Under Light and Dark Conditions

open access: yesAdvanced Science, EarlyView.
This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu   +10 more
wiley   +1 more source

High Frequency Dynamics of the Exchange Rate in Chile [PDF]

open access: yes
We estimate a reduced form model for the daily dynamics of the nominal spot exchange rate in Chile. The model does reasonably well in explaining the long and short run dynamics for the peso-dollar exchange rate for the period 2001-2006.
David Rappoport   +2 more
core  

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

open access: yesAdvanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong   +13 more
wiley   +1 more source

Trayectorias de paternidades homosexuales en Chile

open access: yesRevista Latinoamericana de Estudios de Familia
this article exposes the trajectory regarding the process of configuration of homosexual parenthood in men who were fathers in previous heterosexual relationships.
Gonzalo Soto-Guzmán   +2 more
doaj   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo   +9 more
wiley   +1 more source

LANDSAT (ERTS) used as a basis for geological volcanological mapping in the central Andes [PDF]

open access: yes
LANDSAT images of the central Andes (N-Chile, W-Bolivia) were effectively used for volcanological mapping of an area about 160,000 km. The map shown exhibits more and better details than the older small scale geological maps of that area. Even on a scale
Brockman, C. E., Kussmaul, S.
core   +1 more source

Hyperdroughts in central Chile: Drivers, Impacts and Projections

open access: yesHydrology and Earth System Sciences
Abstract. Owing to the Mediterranean-like and highly variable climate of western South America, moderate droughts (20–30 % precipitation deficit) recur every 3–5 years in central Chile, alternating with wet years. Since 2010, however, this region has experienced a continuous dry spell, including extremely dry conditions in 2019 and 2021, when annual ...
René Garreaud   +15 more
openaire   +2 more sources

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li   +11 more
wiley   +1 more source

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