Results 101 to 110 of about 2,312 (290)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Performance of Low-chill Peaches in Low-chill Area of Taiwan

open access: yes, 2013
最近16年來經由臺灣省農業試驗所園藝系(海拔高度約85m,東經120°40'54'',北緯24°1'59'')保存自國外引進的毛桃與油桃(Prunus persica Batsch)栽培種與優選雜交後代不下65品系,其中需冷量在200低溫單位以內,適應性良好的低需冷量桃與油桃約有30品系,亦即包括本地種桃樹、國外栽培種與優選後代等。本研究利用這些品系爲材料,評估花期表現、果實發育日數、果實品質分析與性狀好壞,以深入瞭解這些種原,期能加以應用優良品系中7612與7669爲本所人工雜交的優選後代。7612由'
宋家瑋   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Climate Change and Crop Exposure to Adverse Weather: Changes to Frost Risk and Grapevine Flowering Conditions.

open access: yesPLoS ONE, 2015
The cultivation of grapevines in the UK and many other cool climate regions is expected to benefit from the higher growing season temperatures predicted under future climate scenarios.
Jonathan R Mosedale   +2 more
doaj   +1 more source

POPULATION GENETIC ANALYSIS OF BRAZILIAN PEACH BREEDING GERMPLASM

open access: yesRevista Brasileira de Fruticultura, 2017
Peach has great economic and social importance in Brazil. Diverse sources of germplasm were used to introduce desirable traits in the Brazilian peach breeding pool, composed mainly by local selections and accessions selected from populations developed by
LIANE BAHR THUROW   +4 more
doaj   +1 more source

Enabling Breeding for Targeted Heat Requirement in Peach

open access: yes, 2022
Peach [Prunus persica (L.) Batsch] germplasm varies in heat requirement and bloom time. This variability can be utilized in breeding for targeted environment or overall climate resilience.
Atagul, Omer
core  

Chilling requirements of apple cultivars grown in mild Australian winter conditions

open access: yes, 2020
Future climate change is predicted to lead to reduced winter chill accumulation in many temperate fruit-tree growing regions of the world. Reliable measures of chilling requirement (CR) are necessary for growers in mild winter production locations to ...
Parkes, Heidi   +3 more
core   +1 more source

Determination of chilling requirements for anthocyanin accumulation in blood orange ‘Tarocco Ippolito’

open access: yesJournal of Agriculture and Food Research
Cold exposure is a key factor in anthocyanin accumulation during the postharvest period of blood oranges; however, its role in the accumulation of these compounds while the fruit is still on the tree has not been investigated.
Adrián Giménez-Sanchis   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Estimación de la disponibilidad de frío invernal para cerezos de la zona norte de la provincia de Mendoza, Argentina Winter chill availability estimation for sweet cherries in northern Mendoza province, Argentina

open access: yesAgriscientia, 2010
Durante el reposo invernal los frutales de clima templado deben estar expuestos a bajas temperaturas para satisfacer sus necesidades de frío. La disponibilidad de frío varía entre regiones y entre años, y puede ser insuficiente para los cerezos.
G. Naranjo, E. Tersoglio
doaj  

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