Results 81 to 90 of about 2,312 (290)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Productivity definition of the chilling requirement reveals underestimation of the impact of climate change on winter chill accumulation

, 2018
Evaluation of chilling requirements (CR) of cultivars of temperate fruit trees provides key information to assess regional suitability, according to winter chill, for both industry expansion and ongoing profitability as climate change continues ...
Rebecca Darbyshire, José Quero-García, José Antonio Campoy, Elisabeth Dirlewanger, Bénédicte Wenden   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Use of phenoclimatic models to estimate the chill and heat requirements of four sweet cherry cultivars in Italy

, 2017
During their dormant period, fruit trees require a certain amount of relatively low temperatures to complete bud differentiation processes and regularly resume growth the following spring.
Giovannini, D., Palasciano, M., Marra, F. P., CARUSO, Tiziano, M. Palasciano, MARRA, Francesco Paolo, D. Giovannini, G. Bassi, F.P. Marra, S. Sirri, T. Caruso, Gaeta, L., L. Gaeta, Sirri, S., Caruso, T., Bassi, G., PALASCIANO, Marino   +16 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fine Mapping of Chilling Requirement and Bloom Date to Enable Marker-Assisted Breeding of Climate Resilient Peach

, 2021
Peach (Prunus persica (L.) Batsch) fruit is a delicious summer treat appreciated for its sweet, juicy, and aromatic taste all over the globe. With only 44 calories and zero fat per fruit, peach has a great popularity among consumers and producers for its
Demirel, Gizem
core  

TESTING OF APRICOT GENOTYPES FOR THE REQUIREMENT OF COLD EXPOSURE (ENDODORMANCY) DURING THE VEGETATIVE BREAK [TESTOVÁNÍ GENOTYPŮ MERUNĚK NA POŽADAVEK EXPOZICE CHLADU (ENDODORMANCE) V DOBĚ VEGETAČNÍHO KLIDU] [PDF]

Vědecké Práce Ovocnářské
Temperate fruit species need to accumulate a certain amount of cold, which is specific to the cultivar, to complete their life cycle during vegetative break (dormancy).
Radek Vávra, Tomáš Litschmann, Adéla Horčičková   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Temperature efficiency for dormancy release in apricot varies when applied at different amounts of chill accumulation

, 2012
International audienceOur aim was to assess the possible differential effect of increasing temperatures due to global warming on dormancy progression in apricot.
Ruiz, David, M. D. Nortes, Nortes Ruipérez, María Dolores, J. Egea, Nortes, M.D, D. Ruiz, Campoy, José Antonio, J. A. Campoy, Egea, José   +8 more
core   +1 more source