The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Interactions Between Chill-Hours and Degree-Days Affect Carpogenic Germination inMonilinia vaccinii-corymbosi [PDF]
The relationship of cumulative chill-hours (hours with a mean temperature <7.2°C) and heating degree-days (base 7.2°C) to carpogenic germination of pseudosclerotia of Monilinia vaccinii-corymbosi, which causes mummy berry disease of blueberry, was investigated.
H, Scherm, A T, Savelle, P L, Pusey
openaire +2 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Implications of climate model selection for projections of decision-relevant metrics: A case study of chill hours in California [PDF]
Decision-makers today have relatively easy web-based access to climate projections from several different models and downscaled datasets. Yet, there is minimal guidance on the credibility and appropriate use of such models and projections for specific adaptation contexts.
Kripa Jagannathan +2 more
openaire +3 more sources
Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer +11 more
wiley +1 more source
Effect of the Accumulated Effective Chilling Hours at the Pruning Time on Budbreak Table Grape on Dessertic Condition [PDF]
The grape crop is important in Sonora State, Mexico, even though the grape growers have some problems that put in risk its continuity. To decide the moment of pruning time is one of the important decisions that the grower must done, because that depends partly the moment and the magnitude the budbreak appeared.
Fabian Robles-Contreras +3 more
openaire +1 more source
Chilling and Heat Requirements of Temperate Stone Fruit Trees (Prunus sp.)
Stone fruit trees of genus Prunus, like other temperate woody species, need to accumulate a cultivar-specific amount of chilling during endodormancy, and of heat during ecodormancy to flower properly in spring.
Erica Fadón +4 more
doaj +1 more source
Since 2004, Brazil has been the leading exporter of chicken. Because of the importance of this sector in the Brazilian economy, food safety must be ensured by control and monitoring of the production stages susceptible to contamination, such as the chilling process.
Souza, Luiz Carlos de +5 more
openaire +3 more sources
Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara +8 more
wiley +1 more source

