Results 131 to 140 of about 13,455 (285)

Substance, essence and attribute in Spinoza, Ethics I [PDF]

, 1987
Both Descartes before Spinoza and Leibniz after him continued the medieval Aristotelian tradition of 'supernaturalizing' Aristotle's conception of God as first substance, and of treating God as the creator of natural substances. Because Spinoza adopts
Donagan, Alan
core  

Coombs’s chimaera

, 2011
I first encountered that passage at age 9, in <em> The Dinosaurs </em> , by William Stout, William Service, and Bryon Preiss. Peter Dodson quoted it in his introduction to the book, and it really stuck in my head. So much so that I quoted it myself when the opportunity arose, and now present it here for your consideration.
openaire   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Technical Proposal for FASER: ForwArd Search ExpeRiment at the LHC

, 2018
FASER is a proposed small and inexpensive experiment designed to search for light, weakly-interacting particles during Run 3 of the LHC from 2021-23. Such particles may be produced in large numbers along the beam collision axis, travel for hundreds of ...
Ariga, Akitaka, Ariga, Tomoko, Boyd, Jamie, Cadoux, Franck, Casper, David W., Cerutti, Francesco, Danzeca, Salvatore, Dougherty, Liam, FASER Collaboration, Favre, Yannick, Feng, Jonathan L., Ferrere, Didier, Gall, Jonathan, Galon, Iftah, Gonzalez-Sevilla, Sergio, Hsu, Shih-Chieh, Iacobucci, Giuseppe, Kajomovitz, Enrique, Kling, Felix, Kuehn, Susanne, Lamont, Mike, Levinson, Lorne, Osborne, John, Otono, Hidetoshi, Petersen, Brian, Sabate-Gilarte, Marta, Sato, Osamu, Schott, Matthias, Sfyrla, Anna, Smolinsky, Jordan, Soffa, Aaron M., Takubo, Yosuke, Thonet, Pierre, Torrence, Eric, Trojanowski, Sebastian, Zhang, Gang   +35 more
core  

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

The status of shark and ray fishery resources in the Gulf of California: applied research to improve management and conservation [PDF]

, 2009
Seasonal surveys were conducted during 1998–1999 in Baja California, Baja California Sur, Sonora, and Sinaloa to determine the extent and activities of artisanal elasmobranch fisheries in the Gulf of California. One hundred and forty–seven fishing sites,
Bizzarro, Joseph J., Cailliet, Gregor M., Castillo–Géniz, J. Leonardo, Hueter, Robert E., Márquez– Farías, J. Fernando, Smith, Wade D., Tyminski, John, Villavicencio–Garayzar, Carlos J.   +7 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

OR Air Quality: Is it time to consider adjunctive air cleaning technology? [PDF]

, 2018
Barnes, Sue, Carrico, Ruth, Murphy, Cathryn, Twomey, Carolyn, Warye, Kathy   +4 more
core   +1 more source