Results 231 to 240 of about 1,923,383 (256)

Chimeric antigen receptor therapy meets mRNA technology.

Trends in Biotechnology, 2023
Genetically engineered immune cells expressing chimeric antigen receptors (CARs) have emerged as a new game changer in cancer immunotherapy. The utility of CAR T cell therapy against hematological malignancies has been validated in clinical practice ...
Jia-Cai Wu, Wei-gang Wu, Boping Zhou, Bin Li   +3 more
semanticscholar   +1 more source

Nanocomplex‐Mediated In Vivo Programming to Chimeric Antigen Receptor‐M1 Macrophages for Cancer Therapy

Advances in Materials, 2021
Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to its complex ex vivo cell‐manufacturing procedures and low therapeutic ...
Mikyung Kang, Seong-ho Lee, Miji Kwon, Junho Byun, Dongyoon Kim, C. Kim, Sa-Gang Koo, S. Kwon, Sangjun Moon, Mungyo Jung, Jih-Ye Hong, Seok-hyeong Go, S. Song, Jaehyun Choi, T. Hyeon, Y. Oh, Hee Ho Park, Byung-Soo Kim   +17 more
semanticscholar   +1 more source

Chimeric Antigen Receptor T-Cell Therapies: Barriers and Solutions to Access.

JCO Oncology Practice, 2022
Chimeric antigen receptor T-cell (CAR-T) therapies are relatively new treatments for patients with heavily pretreated hematologic malignancies. Although these innovative therapies can offer substantial benefit to patients with limited alternative ...
J. Mikhael, Jessica Fowler, N. Shah
semanticscholar   +1 more source

Chimeric antigen receptor-modified macrophages ameliorate liver fibrosis in preclinical models.

Journal of Hepatology
BACKGROUND & AIMS Liver fibrosis and cirrhosis resulting from chronic liver injury are major health burdens worldwide. However, clinical interventions and therapies that target fibrosis remain limited.
Han-Ren Dai, Cheng Zhu, Huai Qian, Wentao Xu, Jiejie Zhu, Xu Zhang, Xian-Zhen Zhang, Bei-Cheng Sun, Hong-Hai Xu, M. Zheng, Xiao-Lei Li, Hua Wang   +11 more
semanticscholar   +1 more source

Critical care management of chimeric antigen receptor T-cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Sandrine Valadè, Peter Schellongowski, Alexander Shimabukuro-Vornhagen   +2 more
exaly  

Chimeric antigen receptor T-cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Sagar Lonial, Rujul Parikh
exaly  

In vivo chimeric antigen receptor (CAR)-T cell therapy

Nature reviews. Drug discovery
A. Bot, Andrew M. Scharenberg, Kevin G. Friedman, Lin Guey, R. Hofmeister, James I Andorko, M. Klichinsky, Frank Neumann, Jagesh V. Shah, Andrew J Swayer, Kyle Trudeau, Drew Weissman, M. T. Stephan, Christian J. Buchholz, Carl H. June   +14 more
semanticscholar   +1 more source

Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors

Proceedings of the National Academy of Sciences of the United States of America, 2023
Omer Dushek, Jesús A Siller-Farfán, Anton van der Merwe   +2 more
exaly  

A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells**

Angewandte Chemie - International Edition, 2022
Jianfeng Zhou, Wenshe R Liu, Shiqing Xu
exaly  

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly