Results 111 to 120 of about 84,650 (262)

Phylogenomic analysis reveals splicing as a mechanism of parallel evolution of non-canonical SVAs in hominine primates

Mobile DNA, 2018
SVA (SINE-R-VNTR-Alu) elements are non-autonomous non-LTR (Long Terminal Repeat) retrotransposons. They are found in all hominoid primates but did not amplify to appreciable numbers in gibbons.
Annette Damert
doaj   +1 more source

What can lithics tell us about hominin technology's ‘primordial soup’? An origin of stone knapping via the emulation of Mother Nature

Archaeometry, EarlyView.
Abstract The use of stone hammers to produce sharp stone flakes—knapping—is thought to represent a significant stage in hominin technological evolution because it facilitated the exploitation of novel resources, including meat obtained from medium‐to‐large‐sized vertebrates. The invention of knapping may have occurred via an additive (i.e., cumulative)
Metin I. Eren, Stephen J. Lycett, Michelle R. Bebber, Alastair Key, Briggs Buchanan, Emma Finestone, Joseph Benson, Rebecca Biermann Gürbüz, Adela Cebeiro, Roman Garba, Anne Grunow, C. Owen Lovejoy, Danielle MacDonald, Erica Maletic, G. Logan Miller, Joseph D. Ortiz, Jonathan Paige, Justin Pargeter, Tomos Proffitt, Mary Ann Raghanti, Teal Riley, Jeffrey I. Rose, David M. Singer, Robert S. Walker   +23 more
wiley   +1 more source

Investigating relationships among strontium, barium, and seasonality in wild baboons

Archaeometry, EarlyView.
Abstract Geochemical profiles of Australopithecus africanus and baboon teeth show fluctuating trace elements, possibly reflecting seasonal diets. Here we use laser ablation–inductively coupled plasma–mass spectrometric measurements of calcium‐normalized strontium and barium ratios (Sr/Ca and Ba/Ca) and ion microprobe analyses of oxygen isotopes (δ18O ...
Maya Bharatiya, Christine Austin, Manish Arora, Janaína N. Ávila, Esme K. Beamish, Wendy Dirks, Daniel R. Green, Nicole D. Leonard, W. Scott McGraw, Larissa Swedell, Ian S. Williams, Jian‐xin Zhao, Tanya M. Smith   +12 more
wiley   +1 more source

Trace Element Patterns in Juvenile Wild Chimpanzee Dentitions

Archaeometry, EarlyView.
ABSTRACT Trace elements are used to infer mammalian early‐life diets, environmental toxins, dispersal patterns, stress histories, and weaning ages. Here, we employ laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) to reveal elemental patterns in our closest living relatives, chimpanzees.
Tanya M. Smith, Manish Arora, Maya Bharatiya, Nicole Leonard, Jian‐xin Zhao, Christine Austin   +5 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Evolution of the NANOG pseudogene family in the human and chimpanzee genomes

BMC Evolutionary Biology, 2006
Background The NANOG gene is expressed in mammalian embryonic stem cells where it maintains cellular pluripotency. An unusually large family of pseudogenes arose from it with one unprocessed and ten processed pseudogenes in the human genome. This article
Maughan Peter J, Fairbanks Daniel J
doaj   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Comparative analysis of cancer genes in the human and chimpanzee genomes

BMC Genomics, 2006
Background Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute to their distinct cancer ...
King Mary-Claire, Bertranpetit Jaume, Gutiérrez-Fernández Ana, Velasco Gloria, Puente Xose S, López-Otín Carlos   +5 more
doaj   +1 more source

Neurophysiological and Behavioral Studies of Chimpanzees Semiannual Report, 1 Jul. - 31 Dec. 1966 [PDF]

Computer program for control of chimpanzee discrimination test analysis and electroencephalographic response ...
Adey, W. R., French, J. D.
core   +1 more source

Homo luzonensis and the role of homoplasy in the morphology of hominin insular species

Cladistics, EarlyView.
Abstract Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Homo and apomorphies found in upper Pleistocene Homo species.
Pierre Gousset, Jérémie Bardin, Isabelle Rouget, Armand S. Mijares, Florent Détroit   +4 more
wiley   +1 more source