Results 111 to 120 of about 98,552 (325)

Evolution of the NANOG pseudogene family in the human and chimpanzee genomes

open access: yesBMC Evolutionary Biology, 2006
Background The NANOG gene is expressed in mammalian embryonic stem cells where it maintains cellular pluripotency. An unusually large family of pseudogenes arose from it with one unprocessed and ten processed pseudogenes in the human genome. This article
Maughan Peter J, Fairbanks Daniel J
doaj   +1 more source

Should great apes have 'human rights'? [PDF]

open access: yes, 2009
Celebrating 60 years of the Universal Declaration of Human Rights provides an opportune moment to ask whether it is time for the other great apes to be granted ‘human rights’.
Rook, Deborah
core  

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Comparative analysis of cancer genes in the human and chimpanzee genomes

open access: yesBMC Genomics, 2006
Background Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute to their distinct cancer ...
King Mary-Claire   +5 more
doaj   +1 more source

Understanding Genomic Evolution of Olfactory Receptors through Fractal and Mathematical Morphology [PDF]

open access: yes, 2011
Fractals and Mathematical Morphology are immensely used to study many problems in different branches of science and technology including the domain of Biology. There are many more unrevealed facts and figures of genes and genome in Computational Biology.
Arunava Goswami   +5 more
core   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe   +6 more
wiley   +1 more source

Hominin evolution was caused by introgression from Gorilla

open access: yes, 2018
The discovery of Paranthropus deyiremeda in 3.3-3.5 million year old fossil sites in Afar, together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees, and a NUMT ("nuclear mitochondrial DNA segment") on chromosome 5 ...
Nygren, Johan
core   +1 more source

Effects of parachute science on local research capacity 降落伞科学对当地研究能力的影响

open access: yesConservation Biology, EarlyView.
Abstract Strengthening research capacity is essential to address the global biodiversity crisis. Yet, parachute science often undermines this goal, and its prevalence, costs, and benefits are unclear. We analyzed 13,502 publications on primate research that we extracted from Scopus (1960–2022) to evaluate the effects of parachute science on local ...
Li Yang   +11 more
wiley   +1 more source

Neurophysiological and Behavioral Studies of Chimpanzees Semiannual Report, 1 Jul. - 31 Dec. 1966 [PDF]

open access: yes
Computer program for control of chimpanzee discrimination test analysis and electroencephalographic response ...
Adey, W. R., French, J. D.
core   +1 more source

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