Evolution of the
Background The NANOG gene is expressed in mammalian embryonic stem cells where it maintains cellular pluripotency. An unusually large family of pseudogenes arose from it with one unprocessed and ten processed pseudogenes in the human genome. This article
Maughan Peter J, Fairbanks Daniel J
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Should great apes have 'human rights'? [PDF]
Celebrating 60 years of the Universal Declaration of Human Rights provides an opportune moment to ask whether it is time for the other great apes to be granted ‘human rights’.
Rook, Deborah
core
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Comparative analysis of cancer genes in the human and chimpanzee genomes
Background Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute to their distinct cancer ...
King Mary-Claire +5 more
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Understanding Genomic Evolution of Olfactory Receptors through Fractal and Mathematical Morphology [PDF]
Fractals and Mathematical Morphology are immensely used to study many problems in different branches of science and technology including the domain of Biology. There are many more unrevealed facts and figures of genes and genome in Computational Biology.
Arunava Goswami +5 more
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<Note> Use of Caves by Savanna Chimpanzees (Pan troglodytes verus) in the Tomboronkoto Region of Southeastern Senegal [PDF]
Jill D. Pruetz
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Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe +6 more
wiley +1 more source
Hominin evolution was caused by introgression from Gorilla
The discovery of Paranthropus deyiremeda in 3.3-3.5 million year old fossil sites in Afar, together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees, and a NUMT ("nuclear mitochondrial DNA segment") on chromosome 5 ...
Nygren, Johan
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Effects of parachute science on local research capacity 降落伞科学对当地研究能力的影响
Abstract Strengthening research capacity is essential to address the global biodiversity crisis. Yet, parachute science often undermines this goal, and its prevalence, costs, and benefits are unclear. We analyzed 13,502 publications on primate research that we extracted from Scopus (1960–2022) to evaluate the effects of parachute science on local ...
Li Yang +11 more
wiley +1 more source
Neurophysiological and Behavioral Studies of Chimpanzees Semiannual Report, 1 Jul. - 31 Dec. 1966 [PDF]
Computer program for control of chimpanzee discrimination test analysis and electroencephalographic response ...
Adey, W. R., French, J. D.
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