Results 1 to 10 of about 4,594 (185)

Deep insights into the gut microbial community of extreme longevity in south Chinese centenarians by ultra-deep metagenomics and large-scale culturomics [PDF]

npj Biofilms and Microbiomes, 2022
The gut microbes play important roles in human longevity and the gut microbiota profile of centenarians shows some unique features from young adults. Nowadays, most microbial studies on longevity are commonly based on metagenomic sequencing which may ...
Congyong Li, Zhe Luan, Yiming Zhao, Jun Chen, Yanan Yang, Cong Wang, Yujia Jing, Shirui Qi, Zhuanyu Li, Hao Guo, Wenyi Xu, Bowen Zhao, Chongming Wu, Shufang Wang, Yunsheng Yang, Gang Sun   +15 more
doaj   +2 more sources

Single‐Cell Profiling Reveals Distinct Immune Communication Networks in Centenarians and Elderly Controls [PDF]

Aging Cell, Volume 25, Issue 4, April 2026.
Single‐cell profiling of PBMCs from centenarians, their offspring, and elderly controls revealed distinct myeloid‐to‐effector immune cell communication programs. General aging was characterized by SASP‐enriched signaling associated with immunosenescence, whereas healthy aging showed positive immune regulatory signaling associated with enhanced ...
Liwei Qiu, Chen Dong, Rui Zhao, Huiyuan Ye, Jian‐lin Gao, Yizhi Chen, Chi Sun, Zhifeng Gu   +7 more
wiley   +2 more sources

Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly [PDF]

, 2017
Mean difference in annual cognitive change for each mmol/L increment of lipid concentrations, stratified by age.
Chaoran Ma, Jiesi Luo, Pengfei Zhu, Xiang Gao, Xiaoming Shi, Zhaoxue Yin   +5 more
core   +2 more sources

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
doaj   +1 more source

Exploring heart rate variability as a biomarker for frailty: A narrative review

European Journal of Clinical Investigation, Volume 56, Issue 4, April 2026.
Frailty arises from progressive multisystem dysregulation, prompting interest in biomarkers that capture declining physiological reserve. This review positions heart rate variability (HRV) within this evolving biomarker landscape, outlining its physiological basis, analytical domains and relevance to clinical research.
Luca Tagliafico, Silvia Ottaviani, Riccardo Balzano, Stefania Peruzzo, Alessio Nencioni, Fiammetta Monacelli   +5 more
wiley   +1 more source

Association Between Nutrition Status and Cognitive Impairment Among Chinese Nonagenarians and Centenarians

International Journal of Gerontology, 2017
Summary: Background: The association of nutrition status with cognitive impairment has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population.
Shan Hai, Li Cao, Xue Yang, Hui Wang, Ping Liu, Qiukui Hao, Birong Dong   +6 more
doaj   +1 more source

Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease (AD), a neurodegenerative disease, involves early alterations in the gut microbiota. Bile acids (BAs), which are metabolites produced by the microbiota, may impact brain function through the gut‐brain axis. METHODS By reference to multimodal datasets from the Chinese Preclinical Alzheimer's Disease Study (n ...
Wenjie Fu, Xiaowen Chao, Ying Wang, Shu Liu, Jie Wang, Qi Huang, Ying Luan, Peiyang Luo, Yihui Guan, Yingren Mai, Wei Jia, the Alzheimer's Disease Neuroimaging Initiative, Qihao Guo, Tianlu Chen, Xiaowei Ma, Fang Xie   +15 more
wiley   +1 more source

Age- and Gender-Specific Prevalence of Frailty and Its Outcomes in the Longevous Population: The Chinese Longitudinal Healthy Longevity Study

Frontiers in Medicine, 2021
Background: Frailty is an epidemic age-related syndrome addressing heavy burden to the healthcare system. Subject to the rarity, age-, and gender-specific prevalence of frailty and its prognosis among the longevous population remains under-investigated ...
Huai-yu Wang, Huai-yu Wang, Xiaozhen Lv, Xiaozhen Lv, Jian Du, Guilan Kong, Luxia Zhang, Luxia Zhang, Luxia Zhang   +8 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Frailty, comorbidity, disability and poor self-rated health: prevalence of overlaps amongst the oldest-old adults from the Hong Kong Centenarian Study. [PDF]

, 2015
Posters - Scientific Research (Epidemology)INTRODUCTION: The frailty phenotype includes five characteristics: fatigue, weakness, poor endurance, physical illness and weight loss.
Cheung, KSL, Kwan, JSK, Lau, BHP
core