Results 161 to 170 of about 131,127 (291)

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell   +16 more
wiley   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

open access: yesAnimal Research and One Health, Volume 4, Issue 1, Page 105-119, February 2026.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song   +11 more
wiley   +1 more source

Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 324-336, February 2026.
ABSTRACT In‐line Raman spectroscopy combined with accurate quantification models can offer detailed real‐time insights into a bioprocess by monitoring key process parameters. However, traditional approaches for model calibration require extensive data collection from multiple bioreactor runs, resulting in process‐specific models that are sensitive to ...
Maarten Klaverdijk   +3 more
wiley   +1 more source

Comparative Analysis of HEK293 Genomic Variability

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 436-448, February 2026.
An investigation of how HEK293‐derived cell lines adapt genetically to different culture conditions and environmental pressures: despite distinct phenotypes and cultivation histories, comparative whole‐genome analyses of established HEK293 variants as well as newly suspension‐adapted cells revealed a shared, common set of mutations linked to cell ...
Georg Smesnik   +4 more
wiley   +1 more source

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