Results 171 to 180 of about 131,127 (291)

Establishment and Characterization of MCA23, a Novel Mouse Intrahepatic Cholangiocarcinoma Cell Line

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Introduction Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of malignancy. Recent advancements have highlighted the importance of the tumor immune microenvironment in therapeutic responses and prognosis. However, the lack of a mouse‐derived ICC cell line and current mouse models limit explorations of the TME in ICC.
Yuchao He, Yi Luo, Liwei Chen, Yu Wang, Bei Liu, Mengting Sun, Wenchen Gong, Xiangdong Tian, Lin Guo, Qin Zhang, Qiang Wu, Lu Chen, Hua Guo   +12 more
wiley   +1 more source

Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2‐nitroimidazole TAT Conjugate

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal, Akanksha Jain, Ashwini Babu, Chandan Kumar, Madhava B. Mallia   +4 more
wiley   +1 more source

Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Jarrett J. Adams, Levi L. Blazer, Jacky Chung, Minoo Karimi, Taylor Davidson, Bailey Blair, Carlos Waddle, Craig A. Hokanson, Heather A. Bruce, Alexander U. Singer, Eva‐Maria Tombak, Kiira Gildemann, Nele Tamberg, Kaja Kiiver, Mart Ustav Jr, Yue Ma, Luigi Colombo, Lily Jun‐Shen Huang, Stephen W. Michnick, Orson W. Moe, Sachdev S. Sidhu   +20 more
wiley   +1 more source

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination [PDF]

, 2007
H. Nagasawa, Paul F. Wilson, D J Chen, L.H. Thompson, Joel S. Bedford, J B Little   +5 more
openalex  

Profiling and engineering of microRNAs for enhancing recombinant protein productivity in Chinese hamster ovary cells [PDF]

, 2013
Wan Ping Loh, Bernard Liat Wen Loo, Lihan Zhou, Peiqing Zhang, Dong‐Yup Lee, Yuansheng Yang, Kong‐Peng Lam   +6 more
openalex   +1 more source

Cytotoxicity and genotoxicity of glyphosate and Roundup Quickpro on Chinese hamster ovary cells. [PDF]

Sci Rep
Ferdous T, He Q, Zhang W.
europepmc   +1 more source

Reduction of Sphingomyelin Level without Accumulation of Ceramide in Chinese Hamster Ovary Cells Affects Detergent-resistant Membrane Domains and Enhances Cellular Cholesterol Efflux to Methyl-β-cyclodextrin [PDF]

, 2000
Masayoshi Fukasawa, Masahiro Nishijima, Hiroyuki Itabe, Tatsuya Takano, Kentaro Hanada   +4 more
openalex   +1 more source

Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells. [PDF]

Biotechnol Bioeng
Santos M, Johari YB, Biggins L, Elliott NC, Schoenfelder S, Boddireddy M, Fabian DK, Anbar M, O'Callaghan PM, Rugg-Gunn PJ.   +9 more
europepmc   +1 more source

Protein overproduction alters exosome secretion in Chinese hamster ovary cells. [PDF]

Anal Bioanal Chem, 2023
Steć A, Targońska M, Karkosińska E, Słowik M, Płoska A, Kalinowski L, Wielgomas B, Waleron K, Jasiecki J, Dziomba S.   +9 more
europepmc   +1 more source

Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP+ Model of Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
When mitochondria are damaged by MPP+, they produce excess reactive oxygen species (ROS) and release zinc (Zn2+) inside the cell. This surge in zinc overwhelms lysosomes—the cell's major zinc‐buffering organelles—causing their membranes to break down. Leaking lysosomal enzymes then trigger neuronal death. Treatments that reduce ROS, bind zinc, or block
Hyun‐Seung Lee, Sun‐Ah Kang, Jae‐Won Eom, Min Seong Kim, Ji‐Soo Kim, Yang‐Hee Kim   +5 more
wiley   +1 more source