Results 101 to 110 of about 5,769,168 (249)

THE DEVELOPMENT OF A PRODUCTION SCALE TECHNOLOGY OF RECOMBINANT FOLLICLE STIMULATING HORMONE BIOPROCESS IN CHO CELL LINE

Разработка и регистрация лекарственных средств, 2019
The article discusses the development of a production technique for recombinant follicle-stimulating hormone used in the treatment of infertility, in the culture of Chinese hamster ovary cells.
D. A. Gusarov, A. I. Gosudarev, V. D. Gusarova, D. V. Byrikhina, F. M. Izhaeva   +4 more
doaj  

Metabolic model of Chinese Hamster Ovary cells used in a fed-batch fermentation process.

, 2016
Metabolic model of Chinese Hamster Ovary cells used in a fed-batch fermentation process.
Alejandro F. Villaverde (313992), Antonio Barreiro (3281052), Antonis Papachristodoulou (221915)   +2 more
core   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Glucose-Limited Chemostat Culture of Chinese-Hamster Ovary Cells Producing Recombinant Human Interferon-Gamma

, 1992
A Chinese hamster ovary (CHO) cell line expressing recombinant human interferon-gamma (IFN-gamma) was grown under glucose limitation in a chemostat at a constant dilution rate of 0.015 h-1 with glucose feed concentrations of 2.75 mM and 4.25 mM.
Paul M. Hayter, Salmon, Ian, Anthony J. Baines, Ian Salmon, Baines, Anthony J., Curling, Elizabeth M., Strange, Philip G., Alan T. Bull, Elisabeth M. A. Curling, Jenkins, Nigel, Nigel Jenkins, Hayter, Paul M., Bull, Alan T., Tong, Jeremy M., Phillip G. Strange, Jeremy M. Tong   +15 more
core   +1 more source

Identification of a novel high‐prevalence red blood cell antigen on junctional adhesion molecule‐A defines a new blood group system

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Availability of new technologies has accelerated the pace of blood group discovery, with nine of 48 known systems being discovered in the past 5 years alone, and yet uncharacterized antigens remain. This study involved investigations of samples from a female patient presenting with a moderate strength pan‐reactive ...
Tosti J. Mankelow, Louise A. Tilley, Vanja Karamatic Crew, Benjamin Jones, Marina Izak, Liora Muncher, Vered Yahalom, Nicole M. Thornton   +7 more
wiley   +1 more source

Expression of biologically active human antithrombin III in Chinese hamster ovary cells

, 1987
Zettlmeissl G, Ragg H, Karges HE. Expression of biologically active human antithrombin III in Chinese hamster ovary cells. Bio-Technology.
Karges, Hermann E., Hermann Ragg, G Zettlmeiβl, H Ragg, Ragg, Hermann, Hermann E. Karges, H Karges, Zettlmeissl, Gerd, Gerd Zettlmeissl   +8 more
core   +1 more source

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

Experimental Physiology, EarlyView.
Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram   +5 more
wiley   +1 more source

Physics‐encoded transfer learning for scale‐up modeling of CHO cell bioreactors

AIChE Journal, Volume 72, Issue 10, October 2026.
Abstract Developing reliable predictive models for mammalian cell bioreactors, particularly Chinese hamster ovary (CHO) cultures widely used in biopharmaceutical manufacturing, remains challenging due to severe data scarcity in industrial‐scale reactors.
Muyang Li, Ming Xiao, Zhe Wu
wiley   +1 more source

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

American Journal of Hematology, Volume 101, Issue 10, Page 2571-2580, October 2026.
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou, Ping An, Wen Xie, Yujuan Guan, Qingfang Xiong, Hong Wu, Huiguo Ding, Yu Chen, Rongkuan Li, Zhili Wen, Mingqin Lu, Jinhui Yang, Zhongyin Zhou, Yongjian Zhou, Zujiang Yu, Kecan Lin, Wei Wang, Yan Huang, Yuemin Nan, Xinhua Luo, Rongshu Shi, Yi Kang, Tao Han, Shiyan Chen, Kai Wang, Yunfeng Shan, Jiaping Li, Pingguo Liu, Zheng Lu, Jun Chen, Zhen Liu, Liaoyun Zhang, Li Yang, Jifang Sheng, Zhan Zeng, Yanyan Yu, Xiaoyuan Xu   +45 more
wiley   +1 more source

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2613-2628, October 2026.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu, Antonio del Rio Chanona, Cleo Kontoravdi   +2 more
wiley   +1 more source