Results 121 to 130 of about 5,769,168 (249)
, 1985 Induction of sister-chromatid exchanges in Chinese hamster ovary cells of biotic ketoaldehyde ...
FAGGIN P. +3 more
core +1 more source
The effect of modulating membrane lipid composition on the thermal sensitivity of tumour cells in culture [PDF]
, 1989 The plasma membrane, which separates intracellular contents from extra cellular milieu, consists of a lipid bilayer comprising mainly phospholipids and cholesterol together with various functional proteins, which control the interaction of the cell with ...
Kingston, Catharine Alison
core
, 2007 Pompe disease is a rare autosomal recessive myopathy due to the deficiency of lysosomal acid alpha-glucosidase. Clinical phenotypes range from the severe classic infantile form (hypotonia and hypertrophic cardiomyopathy), to milder late onset forms ...
Giuseppina Mansi +19 more
core +1 more source
Journal of Applied Toxicology, Volume 46, Issue 10, Page 3446-3454, October 2026.ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal +5 more
wiley +1 more source
Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang +9 more
wiley +1 more source
Fantastic genes and where to find them expressed in CHO
Computational and Structural Biotechnology JournalThe transcriptome of Chinese hamster ovary (CHO) cells plays a crucial role in determining cellular characteristics that are essential for biopharmaceutical applications.
Markus Riedl +3 more
doaj +1 more source
The effect of hyperthermia on the phosphoinositide signalling system of tumour cells [PDF]
, 1994 The effect of heat on the phosphoinositide signalling pathway was investigated in CHO-K1 cells and WRK-1 cells. Heat caused a decrease in 1,2-diacylglycerol (1,2- DAG) levels but did not have any effect on monoacylglycerol (MAG) levels in both cell types.
Kwong, Wing Yee
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INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol
BJU International, Volume 138, Issue 4, Page 607-619, October 2026.Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan +13 more
wiley +1 more source
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Chinese Hamster Ovary Cells, Recombinant Protein Production
Recombinant therapeutic proteins represent a major class of biopharmaceuticals. They are produced in various hosts including bacteria, yeast, cultivated mammalian and plant cells, and transgenic plants and animals.
Chenuet, Sébastien +2 more
core +1 more source