Results 141 to 150 of about 5,769,168 (249)

Overexpression of miR-32 in Chinese hamster ovary cells increases production of Fc-fusion protein. [PDF]

AMB Express, 2023
Bazaz M, Adeli A, Azizi M, Karimipoor M, Mahboudi F, Davoudi N.   +5 more
europepmc   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells. [PDF]

Commun Med (Lond), 2023
Alpuche-Lazcano SP, Stuible M, Akache B, Tran A, Kelly J, Hrapovic S, Robotham A, Haqqani A, Star A, Renner TM, Blouin J, Maltais JS, Cass B, Cui K, Cho JY, Wang X, Zoubchenok D, Dudani R, Duque D, McCluskie MJ, Durocher Y.   +20 more
europepmc   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, Volume 41, Issue 9, Page 670-681, September 2026.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, Volume 183, Issue 18, Page 5641-5656, September 2026.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Assessment of TiO₂ Nanoparticle Impact on Surface Morphology of Chinese Hamster Ovary Cells. [PDF]

Materials (Basel), 2022
Batiuskaite D, Bruzaite I, Snitka V, Ramanavicius A.   +3 more
europepmc   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, Volume 293, Issue 18, Page 5541-5557, September 2026.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani, Sadequl Islam, Emma Filip, Kevin Catalfano, Shravan Paswan, Vaishnavi Nagarajan, Heather M. Wilkins, Brian S. J. Blagg, Kun Zou, Michael S. Wolfe   +9 more
wiley   +1 more source

Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells. [PDF]

Nucleic Acids Res
Domingues-Silva B, Seixas AF, Azzalin CM.   +2 more
europepmc   +1 more source

Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells. [PDF]

Front Bioeng Biotechnol, 2022
Li ZM, Fan ZL, Wang XY, Wang TY.
europepmc   +1 more source