Results 61 to 70 of about 612,123 (288)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Age validation of Han Chinese centenarians.

Genus, 1999
Udgivelsesdato: null ...
Wang, Z, Zeng, Y, Jeune, B, Vaupel, J W
openaire   +2 more sources

RHC genotyping in Chinese Han population

, 2023
Abstract The Rh blood group is a complex, polymorphic system with 56 antigens. Accurately predicting the presence of the C antigen using genotyping methods has been challenging. This study aimed to evaluate different genotyping methods for C predicting and identifying associated genetic variations in the Chinese Han population.
Lin-Nan Shao, Zi-Wei Zheng, Shi-Hang Zhou, Shu-Ting Zhang, Wen-Qian Song, Yue-Xin Xia, Xiao-Hua Liang   +6 more
openaire   +1 more source

Ancestry Informative Marker Set for Han Chinese Population [PDF]

G3 Genes|Genomes|Genetics, 2012
Abstract The population of Han Chinese is ∼1.226 billion people. Genetic heterogeneity between northern Han Chinese (N-Han) and southern Han Chinese (S-Han) has been demonstrated by recent genome-wide studies. As an initial step toward health disparities and personalized medicine in Chinese population, this study developed a set of ...
Qu, Hui-Qi, Li, Quan, Xu, Shuhua, McCormick, Joseph B., Fisher-Hoch, Susan P., Xiong, Momiao, Qian, Ji, Jin, Li   +7 more
openaire   +2 more sources

Circular Polarization in Pulsar Integrated Profiles: Updates

, 2006
We update the systematic studies of circular polarization in integrated pulse profiles by Han et al (1998). Data of circular polarization profiles are compiled.
Biggs J D, Crawford F, Gil J A, Gould D M, Hamilton P A, Han J L, Jin-lin Han, Kramer M, Kramer M, Lommen A N, Lyne A G, Macquart J P, Manchester R N, Manchester R N, McCulloch P M, Melrose D, Navarro J, Petrova S A, Qiao G J, Qiao G J, Radhakrishnan V, Roberts M S E, Stairs I H, van Ommen T D, von Hoensbroech A, von Hoensbroech A, Weisberg J M, Weisberg J M, Xiao-Peng You, Xilouris K M, Xu R X   +30 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Polymorphism of CONNEXIN37 gene is a risk factor for ischemic stroke in Han Chinese population

Lipids in Health and Disease, 2018
Background Stroke has a high fatality and disability rate, and is one of the main burdens to human health. It is thus very important to identify biomarkers for the development of effective approaches for the prevention and treatment of stroke. Connexin37
Hong Li, Shasha Yu, Rui Wang, Zhaoqing Sun, Xinghu Zhou, Liqiang Zheng, Zhihua Yin, Yingxian Sun   +7 more
doaj   +1 more source

Body weights in Han Chinese populations

Chinese Science Bulletin, 2014
The body weights of 26,954 Han Chinese adults in 67 areas (16,503 in rural areas and 10,451 in urban areas) across China were measured from 2009 to 2013. The results showed that in China, the three areas (north China, northeast China, and Jianghuai Plain) were with the greatest body weight. Northwest Han Chinese populations were heavier.
Yonglan Li, Lianbin Zheng, Huanjiu Xi, Keli Yu, Shunhua Lu, Jinyuan Tian, Xue Song, Jinping Bao, Yuling Li, Xinghua Zhang, Youfeng Wen, Fu Ren   +11 more
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source