Results 231 to 240 of about 339,190 (282)

A Biochar‐Based Composite Hydrogel Microenvironment for Enhanced Biocatalysis

open access: yesAdvanced Materials, EarlyView.
This work presents the synthesis of a polyacrylamide hydrogel wherein biomass‐derived biochar is co‐encapsulated with the enzyme horseradish peroxidase (HRP). The resulting composite hydrogel possesses balanced electron‐rich and electron‐deficient domains, creating an optimal microenvironment that concentrates both hydrogen peroxide and phenol ...
Shengzhe Wang   +9 more
wiley   +1 more source

FTO rs1121980 polymorphism contributes to coronary artery disease susceptibility in a Chinese Han population. [PDF]

open access: yesLipids Health Dis
Min X   +9 more
europepmc   +1 more source

Photoresponsive Adaptive Reconfiguration of Single‐Atom Interface With Intermittent Light and Soft Ionic Lattices

open access: yesAdvanced Materials, EarlyView.
We present a photoresponsive platform that integrates SACs with halide perovskite supports, turning perovskite ion mobility, typically a stability concern, into a functional mechanism for light‐regulated self‐repair and reversible atomic reconfiguration. Adaptive metal‐support interactions are established through bandgap‐funnel engineering and the soft
Li Yu   +10 more
wiley   +1 more source

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

open access: yesAdvanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu   +8 more
wiley   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

open access: yesAdvanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu   +15 more
wiley   +1 more source

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