Results 71 to 80 of about 1,073,334 (311)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nineteenth-Century China [PDF]
, 2020 Materials from the past that wrongly anticipate the future, or present information or judgments that are later proved misleading or erroneous, are sometimes overlooked in reconstructing the past.
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2020 The Qing state, driven by Confucian precepts of good government and urgent practical needs, committed vast resources to its granaries. Nourish the People traces the basic practices of this system, analyzes the organizational bases of its successes and ...
Wong, R. Bin +2 more
core +1 more source
Contemporary Chinese Political Economy and Strategic Relations: An International Journal (June 2024) [PDF]
Contemporary Chinese Political Economy and Strategic Relations: An International JournalThis first issue of Volume 10 (2024) of the Contemporary Chinese Political Economy and Strategic Relations: An International Journal (CCPS) offers three select articles and one book review that delves into the Chinese influence in Africa and Central ...
Reymund B. Flores
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2020 Contains two detailed case studies. In “The Fu-t’ien Incident, December 1930,” Ronald Suleski describes the pivotal incident in the power struggle between Mao Zedong and the Communist Central Committee.
Suleski, Ronald, Bays, Daniel H.
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
“Proletarian Hegemony” in the Chinese Revolution and the Canton Commune of 1927 [PDF]
, 2020 The Communist aim of proletarian hegemony in the Chinese revolution was given concrete expression through the Canton Commune—reflected in the policies and strategies that led to the uprising, in the makeup and program of the Soviet setup in Canton, and ...
Thomas, S. Bernard
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source