Results 111 to 120 of about 1,090,658 (370)
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
Nature Methods, 2015 Here we describe the development of a human lung 'small airway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular endothelium that experiences fluid flow, which allows for analysis of organ-level ...
K. Benam +12 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal +2 more
wiley +1 more source
On Implements and Chips From The Floor Of A Palæolithic Workshop [PDF]
, 1880 F. C. J. Spurrell
openalex +1 more source
Science Advances, 2017 An on-chip photonic device mimics the function of synaptic connections between neurons. The search for new “neuromorphic computing” architectures that mimic the brain’s approach to simultaneous processing and storage of information is intense.
Zengguang Cheng +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
BiosensorsSpheroids, as three-dimensional (3D) cell aggregates, can be prepared using various methods, including hanging drops, microwells, microfluidics, magnetic manipulation, and bioreactors.
Chunxiang Lu +8 more
doaj +1 more source
Chip-Firing and Fractional Bases [PDF]
arXiv, 2018 We study a particular chip-firing process on an infinite path graph. At any time when there are at least $a+b$ chips at a vertex, $a$ chips fire to the left and $b$ chips fire to the right. We describe the final state of this process when we start with $n$ chips at the origin.
arxiv
Nature Biomedical Engineering, 2017 An in vitro model of the human kidney glomerulus—the major site of blood filtration—could facilitate drug discovery and illuminate kidney-disease mechanisms.
Samira Musah +14 more
semanticscholar +1 more source
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source