Results 61 to 70 of about 1,488,806 (302)

The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity

Molecular & Cellular Oncology, 2017
TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation.
Lang Rao, Youbao Sha, N. Tony Eissa
doaj   +1 more source

Unsupervised Classification for Tiling Arrays: ChIP-chip and Transcriptome

, 2011
Tiling arrays make possible a large scale exploration of the genome thanks to probes which cover the whole genome with very high density until 2 000 000 probes.
Aubourg, Sébastien, Brunaud, Véronique, Bérard, Caroline, Martin-Magniette, Marie-Laure, Robin, Stéphane   +4 more
core   +3 more sources

Barrier mechanisms in neonatal stroke. [PDF]

, 2014
Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn, Kratzer, Ingrid, Vexler, Zinaida S   +2 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Design of Thermoelectric Cooling System for Heat Removal from Non-uniform Distributed Heat Source in Cell Phones

Zhileng xuebao, 2022
In this study, the problem of heat dissipation of non-uniformly distributed hot spots in high-power chips used in cell phones was investigated. A cell phone chip was used as a heat source, and software was used to accelerate the operation speed and ...
Zhang Jinyang, Cao Lili, Miao Min
doaj  

A Surface Acoustic Wave (SAW)-Based Lab-on-Chip for the Detection of Active α-Glycosidase [PDF]

, 2022
Mariacristina Gagliardi, Matteo Agostini, Francesco Lunardelli, Alessio Miranda, Antonella Giuliana Luminare, Fabrizio Cervelli, Francesca Gambineri, Marco Cecchini   +7 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Complete gradient-LC-ESI system on a chip for protein analysis [PDF]

, 2005
This paper presents the first fully integrated gradient-elution liquid chromatography-electrospray ionization (LC-ESI) system on a chip. This chip integrates a pair of high-pressure gradient pumps, a sample injection pump, a passive mixer, a packed ...
Lee, T. D., Shih, J., Tai, Y. C., Xie, J.   +3 more
core  

Optical interconnect with densely integrated plasmonic modulator and germanium photodetector arrays [PDF]

, 2016
We demonstrate the first chip-to-chip interconnect utilizing a densely integrated plasmonic Mach-Zehnder modulator array operating at 3 x 10 Gbit/s.
Bauerle, B, Chen, H, Dalton, LR, Elder, DL, Fedoryshyn, Y, Haffner, C, Hafner, C, Heni, W, Hillerkuss, D, Hoessbacher, C, Josten, A, Leuthold, J, Salamin, Y, Van Campenhout, J, Van Thourhout, Dries, Wehrli, S, Zahner, M   +16 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source